The molecule complexity is essential for drug development

The molecule complexity is essential for drug development
The complexity of the molecule is that the drug development makes the factor of key to success.


The one that it is reported from limiting nature " Five rules of one li of guest's Sri Lankan bases " Since guilding principle on come out 1997, some main characteristic of molecule, for example molecule quality attempt to cement relations with rulers of minority nationalities lipoprotein nature, getting people's concern day by day as an appropriate medicine candidate's important characteristic as to them. But as the intersection of American and scientist put emphasis on at " the medical The Chemicals " that publish newly exactly, up until now, a kind of characteristic considered directly yet of relevant drug development is the complexity of the molecule. Through analyzing a more than 2 million kinds of compounds database - -These data took a sample and researched and developed every stages in the course from the medicine, researchers produced evidence, indicate the complexity of a molecule is finding from the medicine, get, test, get whom medicine examine and approve transform one key decisive factor that course can succeed finally while being a series of while being clinical.

FrankLovering and colleague of Harvard Medical School, Cambridge, Massachusetts state of U.S.A. have chosen two kinds of measurement methods to reflect the molecule complexity: Quantity of intensity and the hand centre of the saturation chemical bond. The basic principle of back of this choice lies in the saturation increase intensity - -Hybridized carbon ( Fsp3) by sp3 Passage institute limit - -Make compound until three-dimension take in shape, and hand the intersection of centre and increase of quantity strengthen potential different quantity to construct body of compound. It contributes to improving the interaction with the target protein that these kind of effect is acted on the member shape general, raise the latent energy sum of drug candidate ' Or) The specificity, has and increased the possibility to succeed in developing a new medicine. The more important thing is, these effects are not fully increasing the molecule quality - -A key consideration of medicine analogy emphasized in five rules - -Prerequisite lay realize.

Utilize these to determine the method, researchers have analyzed that have GVKBIO database that the compounds of different stages of drug development form represented. They find from find, expire to a clinical test stage, until final medicine state, Fsp3 has increased by 31%. A growth suitable for comparing in the course of developing takes place in the hand centre - -Though some members are got rid of from analyzing because of violating any key element in five rules. Finally, the saturation is found with the solubility - -A kind of physical attribute, success that has already known to be found to the medicine is essential - -Relevant.

Researchers point out, this determines chance of success that Fsp3 can be used for promoting the drug development procedure as a representative of molecule complexities. Utilize and connect the response of the fragrant clan of some levels compound - -In recent years because it can formate parallelly and deal with very popularly according to the high flux, it emphasized an important limitation of the synthetic chemical storehouse used for sifting checking at the same time. So this research employs offering support more extensively for this kind of method, for example, the ones that point to with the variety are synthetic complicated drug candidate molecule on production structure comes. This discovery uses quilt for researching and developing the further response, thus offer the effective preparation for the fact that the medicine is formated. (beautiful and fragrant flowers)

The molecule complexity is essential for drug development