Utilize genetic characteristic choose, give up smoking treatment become possible

Utilize genetic characteristic choose, give up smoking treatment become possible
Staff reporter Feng WeiDong
To cigarette addict, perhaps will become very easy to want to give up this bad habit of smoking soon. First affirmation of the researchers of U.S.A. drug abuse research institute, Duke University medical center, University of Pennsylvania and Brown University, the gene is obviously influencing the personal response to particular treatment of giving up smoking.

In order to confirm that can determine the gene of the therapeutic effect, researchers have scanned whole human genome, find that several kinds of hereditary variation seem to indicate it have possibility to give up craving for tobacco that the nicotine substitutes the treatment or Ann non- his ketone. This research results are issued on the " ordinary psychiatry " periodical published in the near future.

The intersection of Duke University and nicotine and give up smoking outstanding Dr., Rose of Der, director of research center, say, this research takes a great step in making according to specific smoker's measurements and making the most beneficial treatment. In the following several years, the simple blood of once tests that can provide enough information for doctor to recommend more effective treatment means.

In previous research, researchers have scanned the whole genome of more than 520,000 hereditary marks for the first time, it is in these mark from lasting blood sample of smoker tested to give up smoking and gathering to. After the smoker's gene giving up smoking succeeding in is compared with the unable to give up smoking one of those, researchers find one group of groups presenting the positive result in the genetic mutation more frequently appears in the smoker who has already succeeded in giving up smoking. And this research has verified most hereditary marks confirmed can still predict the possibility to give up craving for tobacco accurately before this.

The nerve dark Hull of George, executive of subsection of biological study of molecule of research institute of U.S.A.'s drug abuse fits, this discovery showed and gave up smoking research work to make great progress, this contributes to understanding why some people can give up smoking more easily than others, also offered the potential clue for that individual offered the pointed treatment.

Nicotine substitute treatment or the intersection of Ann and non- the intersection of he and ketone in help people give up proven at the craving for tobacco already, but they realize by different pharmacology mechanisms.

In research this, researcher analyze 550 participate in DNA of smoker studied to give up smoking, and distribute placebo, nicotine substitute and Ann non- his ketone for them at random. Several weeks later, researchers evaluate effect of giving up smoking, the smoker finding 41 kinds of hereditary variation in order to succeed in utilizing nicotine substitutes to give up smoking is exclusive, 26 kinds are the exclusive gene of Ann non- his ketone. Researchers say, everybody has some editions of these genes, but different persons have different mutations.

Researchers emphasize, it is not enough to totally predict the succeeding or not of particular treatment to only have the mutant existence of heredity yet, not deep enough yet to the understanding worked in the course of giving up smoking of these genes. Probably each gene has its influence, perhaps can influence each other during each gene too, researchers can only obtain total influence at present.

The next step, researchers plan to try to verify these are found tentatively, and plan to study and expand Wahlen and Nicklin (Varenicline) With other treatments of giving up smoking, through inspecting the genetic prediction result of behavior therapy, judge that the best therapeutic method appears.



Utilize genetic characteristic choose, give up smoking treatment become possible