Three kinds of biological phenomena that the wound repairs discovering

Three kinds of biological phenomena that the wound repairs discovering
It is reported PLA the intersection of general hospital and first affiliated hospital Professor of Xiao soldier skin tissue finished to take the lead in Fu damage excessive pathology the intersection of repair and new mechanism find and application study go through 12 Tackle key problems every year, find normal wound surface heal in the course having ripe the intersection of epidermis and cell go phenomenon that split up to the intersection of epidermis and stem cell or the intersection of stem cell and kinds of cell for the first time at home and abroad, the system has expounded it causes cell and molecular mechanism taking place in excessive pathology repair that the cell phenotype changes, have set up and kept the treatment technology of the adipose tissue of surviving in the wound surface is treated in early days. This achievement obtains the second prize of National Prize for Progress in Science and Technology of 2008.

Soldier Fu Xiao,etc. is in the country " 973" Under subsidy such as project, national natural science fund project, have found 3 kinds of biological phenomena not reported in the past in the world through studying. First, there is phenomenon that ripe epidermis cells split up to one kind of cells of epidermis stem cell or stem cell while the normal wound surface heals; Second, until typical excessive pathology repair organize, epidermis cell can divide into, succeed fibrous cell under certain the intersection of factor and function, exactly secrete outside the afterbirth in a large amount the ground substance causes the important cytologic foundation emerging in excessive pathology repair; Third, epidermis cells can also divide under certain condition into the inflammatory cell, a large number of inflammatory mediums produced of its are exactly stimulated into the important adjustment factor that a fibrous cell secretion function is further hyperfunction continuously.

Development learns and compares biological study and clinical case study prove, it is to cause important inducement and cytologic foundation taking place in excessive pathology repair to repair the cell phenotype and change, but the wound surface microenvironment influences the important adjustment factor of repairing the cell phenotype and changing disorderlily.

Because of the above-mentioned research, researchers propose " in order to resumes wound surface and repair some microenvironment and control and repair cells to unusually split up to lighten excessive pathology repair " Academic for view,and set up in treating wound surface in if you can't keep, adipose tissue last methods new to repair quality after surviving. This technology faces the application of bed to 1175 cases of wound through domestic over 20 hospitals, heal time to obviously shorten in early days, anaphase cicatrix takes shape and obviously lightens, heal and achieve the Taxi color and luster, elasticity to obviously improve.

It is reported, the above-mentioned research results are issued in academic periodicals such as internationally famous medical magazine " lancet ", " bioscience ",etc., and have guidance functions to research and development and clinical practice of 4 genetic engineering countries and a kind of new medicine. (Zhang Xian cherishes)



Three kinds of biological phenomena that the wound repairs discovering