Utilize RNA interference to resist HIV

Utilize RNA interference to resist HIV
Author: Mei Jin
The antibody can help to transport siRNAs to immune cells, in order to resist HIV. (The picture is offered: Getty)

It is reported American scientist develop one utilize antibody short chain RNA (siRNAs) recently Send to the method of immune cells directly, and interfere with helping to inhibit the infection to the little mouse of HIV virus greatly through RNA. The relevant thesis is published in the " cell " magazine online on August 7.

That carried on this research is PritiKumar and colleague of American Harvard Medical School. Utilize antibodies to tie CD7 protein in surface of T cell definitely while studying, and T cells are exactly one of the main cell types that HIV infects. Researchers affix siRNAs to antibody, later " single-minded " The ground is sent to T cells.

Researchers have used 3 kinds of different siRNAs. A kind of hindrance HIV is produced for the surface receptor albumen which enters T cells; Other two kinds are the mark HIV gene, if HIV manages to enter T cells, they will prevent its duplication.

Kumar says: "Prevent and healing solution it proves to be successful. Obviously, siRNAs hinders HIV from entering most T cells, and once HIV manages to slip away in, they will prevent its duplication too. " This kind many to attack, too can reduce HIV to treat risk to produce person who resist again.

JohnRossi of city Beckmann research institute that U.S.A. hopes says: "This kind of tactics may be developed the clinical practice of the mankind in pairs. " RameshAkkina of the state university of Colorado of U.S.A. thinks: " this kind of method may help to reduce and resist the standard high-efficiently and go against and duplicate the virus treatment (HAART) Reactionless patient virus amount. " But he says, if antibody - siRNA association has initiated the unexpected response of the immune system, this treatment may become invalid.

Utilize RNA interference to resist HIV