Liu GuoSong: It is " old and feeble " to

Liu GuoSong: It is " old and feeble " to confront with each other Sea belong to scientist
Liu GuoSong, the study of medical college of Tsing-Hua University and director of research center of memory, part-time professor of branch school of Austin of U.S.A. Texas university. Selected in Tsing-Hua University in July of 2005 " The plans of one hundred people " , the Changjiang River scholar's professor invited specially, accept an appointment of the medical college of Tsing-Hua University and serve as the professor, dictorial supervisor. Obtained great project support and country of National Natural Science Foundation of China in 2006 " 973" Project support. The main research direction is at present in its laboratory: Plasticity of nervous system and research that the nervous system network forms and optimizes; Study the basic principle with memory and study and strengthen memory and resist old and feeble new medicine development of the brain.

Hao Jun

In visit in the telephone nearly, Liu GuoSong of straight talk from an honest man without mincing words: "I do not like giving an interview very much. " The reporter proves that comes for hundredth anniversary of the founding of the school of Tsing-Hua University, he has promised our interview invitation.

"Four thirty in the afternoon. Enter the northwest door of Tsing-Hua University, keep straight on in medical building of reddish brown on right-hand side of 100 meters southwards. " Liu GuoSong tells time and place that reporters meet with the scientist's accuracy. In an ordinary workday afternoon, the reporter went to the medical college of Tsing-Hua University to visit this low-key internationally famous neurobiologist.

The alien comes back

The appointed meeting room, its study and memory of taking on the director study the central lab. Before interviewing, reporter Zeng Cong " water wooden Tsing-Hua University " See such description on the forum: " the intersection of Tsing-Hua University and the intersection of medical college and study and the intersection of memory and research center, by internationally famous the intersection of nerve and biological the intersection of expert and him in American Massachusetts Institute of Technology (MIT) Liu GuoSong Professor Study and memory laboratory translate and get by Tsing-Hua University one that set up. "

This recruits doctor's model that come to the loose laboratory in the Liu 's to take an advanced study and study, release time as September of 2005. In two months before this, Liu GuoSong is selected in Tsing-Hua University " plans of one hundred people " ,Engaged as the Changjiang River scholar's professor invited specially and serve as the professor of medical college, dictorial supervisor.

He has finished oneself in life of U.S.A.'s the past 20 years -long scientific research, gets back to China carrying new dream in its one of careers peak.

Before coming into Tsing-Hua University, top university of our country and taking office, his scientific research career abroad lets people admire very much. From 1985 to 1993, went through the Los Angeles branch school of University of California (UCLA) The intersection of the neural physiology and professional Dr., the professional post-doctor of department's nerve physiology of UCLA physiological science, studying the assistant professor; From 1993 to 1996, molecule living beings and cell physiology of Stanford University were professional post-doctors of the neural physiology; From 1996 to 2005, let the intersection of MIT and brain and the intersection of cognition and scientific department, biological the intersection of department and assistant professor successively, the intersection of Picower and study and researcher, centre of memory, brain and the intersection of cognition and scientific department, biological the intersection of department and associate professor. But in 2005, were engaged as University of Texas at Austin and studied the chief professor of part-time job with the memory research center.

The easy shirt matches the jeans, Liu GuoSong is with classical " American scientific research people " The image appears in front of the reporter. Without surplus exchanging a few words of greetings, he heads direct for the theme and starts a conversation, experience and feeling in five years that have a chat to get up and return to the homeland.

To unknown love

Busy, it is the first appraisal on the domestic scientific circles atmosphere of Liu GuoSong. Liu GuoSong learnt for one's own work these five years " Do the subtraction " ,He chooses to refuse the administrative function beyond much academy politely, he says that has guaranteed to have sufficient time to devote oneself to the scientific research that he loves like this.

" whether unwilling to have dealings with media, the intersection of I ' subtraction ' and first in the the principles too, " GuoSong Liu say in a joking way subsequently, he explain oneself tries hard to far away from the reason of the media to reporter, "the scientist's job is to utilize their scientific findings to work for the welfare for the mankind, the propaganda of the media is appropriate. "

A media invited Liu GuoSong who attacks anti-aging research mainly to explain " The maintaining good health by scientific methods " ,It is getting more real still in one's own to joke he research somewhat like " Keep in good health " ,But in abstruse scientific research in fact after all, most masses very much difficult to understand, so has refused to appear on TV.

Seem, do science will certainly fill love to science while being loose in country Liu. Choose the scientific road, must think scientific itself is very interesting, make and like scientific research in the bottom of heart. He tells one's own student, if regard scientific research as the work of making a living, that must be very difficult, it is not a good job. If not really like science, it is good that that leaves this field earlier.

"Can find out about unknown thing, we are very glad. Science prepares for exploring the person of spirit. " Liu GuoSong thinks that it is actually very simple to become a real scientist, should just love oneself of interest and scientific.

The laboratory is the front that Liu GuoSong never leaves, he said he wanted to discover the problems, want in most primitive position right away. While interviewing, he has told reporter a little story: There is winner of one the Nobel Prize over 70 years old, changes the food for the fruit bat in the laboratory in the nightdress in the evening.

GuoSong Liu want, tell reporter whether first-class scientist must to stand in people that start under laboratory in person with the story.

From cell to brain

Bore Liu GuoSong far away from media in the laboratory, but let the whole world media focus on his scientific findings.

January of 2010, the article " magnesium ion can strengthen brain learning and memory function " that its laboratory of groups will send Issue in the intersection of world and the intersection of nerve and scientific the intersection of field and first-class academic periodical Neuron ' " neuron ") Have. Because this research has " announced magnesium ion as the important regulating action to maintaining brain learning and memory function of two highest price metal of content ion in a kind of cell for the first time, and pointing out may become the important route to prevent and treat old and feeble disease of the brain to supplement magnesium ion " And receive the extensive concern of international community. Britain, U.S.A., Germany, France the intersection of world and all big newspapers and periodicals and domestic media fall over each other report, successively reprinted by nearly 20,000 international websites.

Because of receiving the high concern of neural scientific circles, January of 2011, the top periodical Cell (" cells ") of the biological educational circles Classify this article as the most attractive thesis ( Highlightsof2010) of 2010 .

Liu GuoSong says the research work of that thesis probably took 6 years, but numerous foundations studying are inseparable from accumulation and exploration for over 20 years.

Centre on the research course in 20 years of neural science, he has not expected at first that will attack " study and memory " mainly today And anti-aging problem. While studying in U.S.A. for many years, he concentrate and pay close attention to " density question that the nerve touches suddenly " ,Have found gradually on the cell level that regulates the route to touch plasticity suddenly with the medicine, and finished most theory work.

? Assuare the Huaihe River of core guest wave smell of fish luxuriant tomb 's imperial decree Wei wave awake to cut out from disrespectful 6 industry the intersection of pen and coin cut out, wave core Xi awake to cut out, jab wink yellow Zhen in gruel wooden tablet or slip for writing Xing! Split open Shi and cover Yu.with mat and say the ring of routed locust of Du army Xi Yi of the Huaihe River of guest's sunshine of core of bank Nai is at a disturbance of the horizontal inscribed board to stop Zhyuan Yun and is able to bear the benevolence strong Zhyuan of Du of the Huaihe River and compel now! ?

Its lie in brain old and feeble and key essence of IQ to " touch the question suddenly " while being profound ,The dull-witted main manifestation of old age is the decline of touching the density suddenly. In this way, a neurobiologist relies on " unique rare book " Have rushed into research study, memory and cognitive manor.

Liu GuoSong describes this transition " Insight " ,Then, the window has been opened, it is the more excellent world outside. He stretches one's own research feeler to the brain from the molecule naturally. Studying spans numerous fields such as mathematics, physics, chemistry, project, psychology, molecule living beings gradually too.

Though Liu GuoSong is a genuine biologist, he teaches oneself the engineering in respects such as the computer language, electronic circuit,etc., and is devoted to applying the method of the engineering and thinking to biological study.

At time when MIT works, he finished to touching and calculating the research work of the characteristic in the neural network suddenly alone, propose the biggest difference between signal handling and computer of the nervous system to lie in: There is the treatment to information of nervous system " Three system characteristics " ,Not only not merely have a signal, but also have at the same time - a signal, the article is issued after on " natural - neural science ", not only has aroused the attention from neural educational circles, has but also caused the extensive attention of the computer educational circles, Science also specially writes articles and introduces this result of study. He has also guided the graduate student of MIT, has applied the computer science and technology to scientific research of the nerve, utilize the intersection of engineering and method of printed substrate study hippocampal neuron touch steady state phenomenon since of intensity suddenly in the brain. This research results are spoken highly of 2007 by Science.

"How to let someones keep higher cognitive function level during all one's life, solve the old and feeble problem of brain such as being dull-witted of old age? " Liu GuoSong is said to be this's the major question that he cares about finally, the others are only this " great river " "tributary " . The reason why anti-aging research causes global attention, because the mankind faces the severe senilization social concern day by day.

Small goal, the cosmos of Daewoo

The great progress made in anti-aging research, it is only that his is all application of first about research work of cognitive respect that seem in the Liu 's is loose. At present, he make great efforts, promote whom their research and develop resist old and feeble new medicine of brain and carrying on the human clinical trial in countries such as U.S.A., Germany,etc. with group, in order to verify this new medicine opposes old and feeble clinical result of the brain. "Will also extend to depression and treat and lengthen the research of the life-span in the future. " Liu GuoSong says.

Liu Guo's loose research involves very extensive ambit, whether encounter the bottleneck one during this time? He tells reporters while interviewing, only some swing, but does not have long-time difficulty period ever without the least hesitation. Tracing it to its cause, he says that is because one's own goal is " from childhood " at all times .

"It was the molecule in MIT what I studied at that time, studying memory a little forward, thought it was a very great thing. But find recently, memory is only the whole a cognitive small part. In only half a year in this, I realize and close to solving the cognitive most basic problem. " Liu GuoSong is recommending how one's own goal change from small to big step by step, he explains to the reporter, "I am not at your age of this on the issue that it is complicated and cognitive to solve to think of. One's own goal of standing is very small at all times that I give, but camp step by step all the time, the goal in research is increasing accordingly with the progress of studying constantly too. "

Recalled, Liu GuoSong thought the foundation of all work at present, established 17 years ago. At that time, became the post-doctor's him in Stanford University about touching the first experiment that the density was regulated suddenly while carrying on his research career, and today 17 years later, he sets up and touches the complicated theory frame that the density regulates suddenly. The scientific research in his eyes, the randomness is planned far, so must adjust oneself at any time, lead to more long-range goal finally.

Plant one " The tradition " Its tree

The scientific research careers of more than 20 years abroad, why is in the job " mature stage " Choose to come back home? And the topic which people speak of that perhaps this is Liu GuoSong many times.

When MIT, Liu GuoSong has already found a anti-aging compound, has studied and entered the stage needing to make a large number of animals experiment. Through considering, he thinks these experiments run in China and not have too great difference in U.S.A., perhaps can also do at home better. Can continue making the scientific research of the front of the world, it is the loose basic demand the most that returned to the homeland of the Liu 's.

"Scientist whose our generation came back home, really want to accomplish, hoping to plant a tree. But this tree, it is the fine scientific research tradition. " Liu GuoSong says when he chooses to come back home, the most urgent expectation. He hopes to let the young students of Tsing-Hua University bear the fruit in the native country on this tree, make the achievement that can really compete with world-class university. This is the sea in his eyes the mission which the scientist needs to finish most.

Rise in western modern science, has formed ripe scientific research mechanism and structure in the development of more than 200 years. The sea is said one of the responsibility that he undertake by scientist Liu GuoSong, it is to set up rational and scientific research structure effectively inside a institute department of the school, form the scientific research tradition that can root.

In addition, the second thing of making sure that Liu GuoSong hopes, it is to make some contribution to scientific research system of China of the whole. Compared with overseas scientific and technological developed country, our research system is still in trying to find out, Liu GuoSong can be helpful to making the system in order after hoping to come back home.

"MIT has produced a lot of outstanding achievements in history, it means it must have its advanced places. The old scientist died, the fresh blood came in, has been adhering to one's own tradition while replacing all the time. This is that we want the modest place for study. " Liu GuoSong thinks those are taken " Idealism " Scientists coming back, will all have such expectation, what they pursue is how to let our own research system more orderly, more effective. It is so simple.

As to one's own scientific research, Liu GuoSong says he has a foothold in one's own laboratory, gather to make anti-aging medicine, " I do not pursue superficial fame and gain, make this medicine, it will be a historical thing. Because one's own scientific findings can promote the well-being of mankind, it is scientist's greatest honor " .

At hundredth anniversary of the founding of the school of Tsing-Hua University, " dreams of " when Liu GuoSong hopes to return to the homeland towards it originally Continue striding forward. He believes, while one's own scientific research is making new development constantly, the scientific research level of our country will be developed faster too, also can do better.

Liu GuoSong: It is " old and feeble " to confront with each other Sea belong to scientist