Molecule " floater " Adjust and control the immunity "

Molecule " floater " Adjust and control the immunity " The gate "
It is reported ' The reporter makes quick intern Guo Xin of Qi to exceed) Sometimes, the fatal shock reason does not come from the toxin that the bacterium secretes, but from human immune system " The overreaction " . Have issued the Shanghai scientist's latest find in " natural immunology " published newly this month, a molecule exists in the human body " The floater " ,Can be here " Respond to a call for contributions and go to war " Cell quantities immune last hour to close" The gate " ,It is immune to prevent too many " The main forces " Human organ of attack - -This discovery has offered a kind of new thinking of research for inhibiting septicaemia and shock.

Septicaemia and shock plant the serious inflammatory state, can cause nearly 50% mortality - -When bacteria which infects the human body breed in a large amount, will release the toxicant endotoxin, in order to intercept the invasion of pathogens, the immune system will mobilize various immune cells, and produce a large amount of immune active substance " Stop " ,The immunity that the result swarms forward " The main forces " It is disorderly to cause immunity damaging and small and vascular function instead, result in circulating the obstacle a little, the patient demonstrates little circulatory failure, hypotension, oxygen deficiency, acidosis,etc.. But this " The war out of control " Inside story,scientist unable to grasp the key points or main ideas.

Screen the gene to begin with DNA chip technology from inviting Zhejiang University Professor Xiang ChunSheng, utilize Shanghai of Chinese Academy of Sciences to grow numerous technological platforms of department's institute, has explored for 7 years totally, Chinese Academy of Sciences Shanghai grow department institute biochemistry and cell the intersection of soldier and seminar Sun untie the secret among them.

The tree dashes for ward form cells - -It is important in the human immune system " The scout " ,While meeting virus of bacterium to invade, can follow different " foemans " The kind, send out different " call up making " ,Convene the immune active substance to come " Destroy enemies " . " call up making " Shifting the immunity " The main forces " While,make a quick response another molecule TRIM30 at human body too. It, like the floater on the valve, with " respond to a call for contributions " Immunity " main forces " The quantity is increasing constantly, its density will increase accordingly too, when reaching certain density, it will close " The valve " ,Block " call up making " Continuation release,prevention " the main forces"s immunes too much It causes excessive immunoreaction and organizes damage to react in the cooking stove at human inflammation.

According to the intersection of thesis and main author, the intersection of doctor and Shi Mu Germany and the the intersection of article and introduction, the present little mouse experiment of mode proves, the internal TRIM30 - 's albumen expresses the little more mouse, can oppose shock that the endotoxin caused better, if has inhibited the expression of TRIM30 - , even slight bacterial infection, will cause little mouse septicaemia and shock. The responsible reader of " natural immunology " magazine comments: "This thesis has announced a kind of new mechanism of immunity of inhibiting the inflammation, though study and still only stay on the regular inflammation of the little mouse of experiment, but should find in order to find in the human body the similar mechanism has pointed out the direction. "

Molecule " floater " Adjust and control the immunity " The gate "