Cut off tumour " The supply network "

Cut off tumour " The supply network "
Staff reporter easy the intersection of reporter and Li transport red Zhao meet day such as Li

The accomplice of tumour is a blood vessel

In the treatment of malignant tumour, the chemical drug therapy of whole body can narrow even dispel the tumour piece successfully. But for some time, some is narrowed and even " disappear " Tumour continue again to grow,strengthen by dosage on medicine last results original either. After strong chemotherapy is attacked, why will tumour be " too wild to burn to the limit " (used at the end of a special alternative, or rhetorical question)? The tumour hospital lung tumour head of the department of internal medicine Professor Li Kai of medical university in Tianjin says, an important reason is during the war with the human body among them, malignant tumour can get " logistic supply " continually ,Make them stage a comeback again and again.

Then, who is transporting the nutrient to tumour constantly? This " accomplice " It is a blood vessel.

Li Kai says, when the tumour volume is smaller than cube millimetre - 2 cube millimetres, only depend on " nutritive juice " around (medical science is called " The tissue fluid " )Supporting can survive. But once tumour grow up, centre of it will support oxygen to be enough necrosis. Meanwhile, tumour will secrete a special material - -Urge the blood vessel to produce the factor, and secrete into the blood continually, then enter the bone marrow, irritate the leather cell division in the blood vessel, breed, and form the new blood vessel network at tumour. Once set up one's own one in tumour " The canal network " ,Not only can get the nutrient to grow from the blood vessel rapidly, can also deliver the malignant cells fallen off to any internal place along the blood vessel, and take root, multiply.

Why can not strong chemotherapy medicine kill its new born blood vessel while killing tumour too? This is because newly vascular endothelial cells are the original cells in the body, so can have escaped from the attack of the chemotherapy medicine.

The medical circle wishes eagerly to find the new medicine can attack tumour blood vessel endothelial cells, prevent it from forming blood vessel, make tumour lose and supply " logistic supply " of nutrition ,Thus " die of hunger " Tumour.

Transition of the thinking

At the beginning of the seventies of last century, Buddha, very graceful professor of Harvard University medical college proposed the imagination of the hungry treatment of tumour at first, formed and resisted the blood vessel and produced and treated the concept progressively later. One expert describe this kind of resist blood vessel, it turns into treatments to be " Sea-Air-Land chemotherapy killed to call fight on the world in cry 'kill it' by one in medicine, it is that one are low-key, conceals, the surprise enemy's rear area armed working team " .

However, it is unsatisfactory that the medicine researches and develops result and progress. Though little the intersection of mouse and experiment prove the intersection of blood vessel and the intersection of endothelial cell and whom inhibin have on cancerous swelling obviously that U.S.A. develop dwindle and inhibit curative effect, but this medicine only finished the clinical trial of stage in U.S.A., cut off in 2005.

One's accomplishments are easily known outside his own unit. In the 1990s of last century, a batch of young scientists of our country coming back from U.S.A. tackled key problems with great concentration, utilize " protein " This technology, transform endothelial cell inhibin of blood vessel into our country's own resisting the production medicine of blood vessel - -New medicine kindness degree of one kind. Resist blood vessel turn into medicine to in the human body resting and vascular function very little, will seldom endanger the normal organ.

Are the clinical tactics of resisting the blood vessel and producing the treatment effective? Under the circumstances that the subsidiary tumour hospital academician Sun Yan of academy of sciences of China's medicine organizes, several dozen hospitals in the whole country have participated in the clinical trial. In May of 2005, at U.S.A.'s clinical tumour association's annual meeting, Sun Yan reported that resisted the blood vessel to produce the medicine kindness degree and face a test result of bed in our country: 326 patients accepted that resisted the blood vessel to produce the treatment from 2001 to 2004, there is tumour of the patients of 35.4% that obviously dwindled; 167 patients accept simple chemotherapy, 19.5% of the tumours among them obviously dwindle, its difference has prominent statistics meaning.

According to the newest statistics, over 30 kinds of anticancer drug resisting blood vessel and producing the factor are being carried on clinically or tested in clinical earlier stage in various countries at least at present.

The new method needs more evidences

Though resist the blood vessel and produce the treatment to offer the new route of tumour treatment, Li Kai points out, this is still that one kind, in developing new treatment, a lot of important problems remain to explore. For example, it is still short because of the time of coming out, existing clinical materials and inexperienced, range and depth studied are not enough, potential long-term curative effect and side effect still need to observe.

Li Kai says, in resisting the blood vessel and producing the treatment, resists the blood vessel and produces and carries on with chemotherapy in coordination, many clinical problems being treated were not solved. For example, it is generally acknowledged that resisting the new born blood vessel treatment can lead to the fact the blood of tumour is reduced, it might present tumour exhausted for oxygen state,but how for radiotherapy, chemotherapy increase quick? In resisting the new born blood vessel treatment and uniting the chemotherapy mode, how to confirm the best medicine dosage and for the time of medicine? Should give and resist the blood vessel before chemotherapy and produce medicines? The time dependence of resisting the blood vessel and producing curative effect is stronger than dosage reliance, how long does it take to give medicine? How long to treat? All these need a large number of clinical test results to prove.

The biological rescue center yellow gentle Professor Lin of Zhongshan University tumour hospital points out, it is directed primarily to new born blood vessel sensitive tumour to resist the new born blood vessel treatment, for instance hepatocarcinoma, lung cancer, intestinal cancer, and is not fit for all tumours.

Antitumor weeding out the old and bringing forth the new of different views and schools and constantly, treat the transition of the thinking on the basis of the whole tumour. Kai Li say, for a long time, treat view, limited to, strive for, make the intersection of tumour and the intersection of tumour and body dwindle, so that disappear while being clinical, the short-term result has become the main goal. However, from the end of last century, happening on the strategic thought with therapeutic tumour greatly changes in the medical circle, the unbounded tumour that grows will be changed into a kind of chronic disease that can be controlled soon, can take tumour to survive and lengthen the life and improve life quality while striving for patients.



Cut off tumour " The supply network "