The weight-reducing signal is controlled in the brain "

The weight-reducing signal is controlled in the brain " The reporter "
It is reported ' Reporter Xu QiMin) Already been so fat that the fat overflows, but still can't help not stopping eating obviously - -Perhaps more than 90% of the fat patients do not know, an important " reporter " in it is hypothalamic that theirs in a difficult position comes from nerve centre "unmoved" . Recently, the cooperation of Sino-America scientists has discovered that show, is responsible for the importance " reporter " transmitting the weight-reducing signal in the hypothalamic nerve cell --Thin plain receptor, are controlling a lot of so far unknown weight-reducing signal thorough fares. If these thorough fares is obstructed and causes the thin plain receptor " The non-performance " ,The patient will store the excessive fat until the fat of the morbid state take place. The internationally famous academic publication " publication of institute of American Academy of Sciences " issued this research results recently.

In fact, in the fat is in the body and it is not only a pile of oil as like that as what people generally think, it not only stores a large amount of energy but also will secrete many kinds of hormone known as fat cell factor - -It is the most classical one among them to be thin and plain. Come from " fat " Thin plain,its mission is getting as the same as name of more it, can't be be be be wanted to hypothalamic to transmit by one of informationseddedded - -" thin " . As being thin to arrive hypothalamic usually, activate hypothalamic, behind the tight plain receptor at the nerve cell, receptor will start every the intersection of information transmission and passway, transmit, get down the intersection of mound and low reaches of brain cener ring upon ring information this. After combining and combing information, hypothalamic to order immediately: Inhibit the appetite, accelerate the energy supersession, move quickly, reduce the oil to store

In the past, the scientist had already announced the thin plain receptor had thorough fares of three main signals. But the scientific research personnel of seminar and American University of Texas southwest medical center in Dallas which scientific research institute brave researcher Liu of nutrition of academy of sciences of Shanghai life of Chinese Academy of Scienceses led pass Pass behind the 4 -year long joint study finding, have thin plain the intersection of signal and thorough fare excavated to remain participate in the fat of organism store the control of quantity more in being hypothalamic.

Liu Yong tells reporters, the human body adjusts and controls the weight by unusually meticulous and complicated neural reaction network, but the thin plain receptor is an extremely important ring among them. Discover, have 5% about fat patient because gene in the tight plain the intersection of signal and thorough fare hereditary variation took place mostly in the past, it can not received that hypothalamic " Reduce weight " The signal, thus cause the weight to be out of control. But more fat is because of turning a blind eye to the thin plain signal one: The thin and plain level is not low in patient's blood, even very high, but hypothalamic and still unable to receive " reduce weight " Signal.

Then, the scientists reach the concentration of sight the thin plain receptor this important " reporter " On one's body. Researchers, through carrying on the gene mutation transformation to a group of little mice, make three thin plain receptor signals already known transmit the thorough fare and all " fail " ,Find this group little mouse appetite really unusually vigorous, appetite 50% higher than little mouse normal finally, but the amount of exercise is half of the little normal mice. Give they finally " The physical examination " When find these is little whether because mouse weight last little mouse each normal, account for 40% of weight fat, and the fat of the little normal mouse only accounts for about 20% of the weight.

What is interesting is scientist return contrast, observe another little mouse, this group little tight plain the intersection of receptor and complete disappearance of mouse. They find, this group of little mice can eat more than last group, it is being too fat to reach the food even will have had all the timing; And they are less active, the amount of exercise is only 20% of the little normal mouse, the internal fat has occupied 50% of the weight! "The two compare with having our unknown signal thorough fares to explain the thin plain receptor. " Liu explains bravely, when obstructing in three known main thorough fares, thin and plain still can adjust information through transmitting in other routes; Unless after stopping up death in all thorough fares, getting fatter seriously to be little for mouse" diabetes serious " , " very afraid of cold, will be frozen to death soon under the low-temperature condition " .

"The nutrition reaction network of the central nervous system of organism is intricate, what we know is only the iceberg corner at present. But find conducting the thorough fare of signal of these ' reduce weight ' out, have important meanings in treating fatly, preventing diabetes. " Liu Yong says, his research group is doing the further exploration work, attempts to find each what characteristics there are in the signal thorough fares of these thin plain receptors, especially will order to thin plain signal under the influence of some factors " Unmoved" .

The weight-reducing signal is controlled in the brain " The reporter "