Endotoxin and chronic supersession disease are prominent and relevant

Endotoxin and chronic supersession disease are prominent and relevant
It is reported DiabetesCare issue the intersection of Chinese Academy of Sciences and the intersection of Shanghai and raw the intersection of department and the intersection of institute and the intersection of nutrition and scientific Lin Xu the intersection of group and relevant human endotoxin, researcher of research institute, recently ' Lipopolysaccharide) Conjugated proteln (LBP) The latest find of studying in ill risk of level, supersession syndrome and 2 type diabetes.

This research finds in the crowd of a larger scale LBP and chronic supersession disease are concerned with the relation prominently for the first time, announce it while chronic supersession disease takes place, a group of product endotoxin, as the source induction thing outside one kind of fungus, may play an important role in activating the chronic inflammatory thorough fare.

A large amount of research shows, one of the important mechanisms that fat relevant supersession disease takes place that chronic inflammation is probably. However, it is not yet clear to causing risk factor and relevant mechanism of the chronic inflammation up until now. Animal's experiment reveals, the fatty food or endotoxin can stimulate the chronic inflammatory thorough fare, thus cause the supersession to be disorderly.

The intestinal leather is blue the negative fungus is an endotoxic important source. LBP is one of the key members on the endotoxic thorough fare, it half-life is relatively long, the detection method is steady, can be regarded as the substituting index which reflects endotoxic level of the blood.

Lin Xu seminar grandson on in the overweight / fat crowd (559) With the normal weight crowd ' 500) Relation that the blood plasma LBP level of network analysis is associated with fat and relevant supersession disease, find LBP level is higher than the normal weight individual in the overweight / fat individual notably; Blood plasma LBP level and physique index (BMI) , supersession indexes such as waistline, blood pressure, blood glucose, fat of blood, insulin,etc., and liver enzyme, inflammation factor are correlated with with the fat factor level notably; After controlling age, gender, smoking, drinking, physical exertion, disease family's history and BMI, the research object suffers from the supersession syndrome, insulin resisting and danger of the 2 type diabetes, increase notably with rising of the blood plasma LBP level, these are related but still independent of other dangerous factors, such as liver enzyme and fat factor level; The blood plasma LBP level is associated with supersession syndrome relation and inflammatory factor are horizontal (C reflects albumens and lies between plain 6 in vain) Relevant, the relevant relation between resisting in and LBP level and insulin and 2 type diabetes, but can't totally explain, prove it is possible for other mechanisms to get involved with the inflammatory factor.

This work has received the important direction project of the knowledge innovation project of Chinese Academy of Sciences, international scientific and technological collaborative project of the Ministry of Science and Technology, subject of the scientific research plan in Shanghai, national natural science fund, life chief scientist's project and French country of research institute of Shanghai of Chinese Academy of Sciences study the subsidy of the administration. (yellow and hard)
Endotoxin and chronic supersession disease are prominent and relevant