Inner different disease is still disease difficult to cure

Inner different disease is still disease difficult to cure
In the uterus the intersection of membrane and the intersection of malposition and disease ' Inner different disease) Cause menstruation of women of child-bearing age and infertile main reason, is influencing the masses of women's health, life quality and working efficiency seriously. Though the scientist of various countries launches the work of studying from different internal different diseases of angle in a large amount since 1885, but attend Israel " The mechanism and clinical important issue that intervenes take place in membrane malposition disease in the uterus" Point out, inner different disease foundation and clinical research make little progress for a long time for the expert of the 375th Fragrant Hills scientific meeting of the theme, the onset mechanism is not clear, also lack the effective treatment medicine clinically, different disease is still disease difficult to cure at present.

" mystery " The same cause of disease

The data reveal, the morbidity in the women of child-bearing age of inner different disease is about 10% and have the tendency to obviously rise, 80% of the inner different disease patients pain with the pelvis, 50% amalgamate sterility, it is to influence young and middle-aged woman's healthy common disease and frequently-occurring disease seriously. Though inner different disease is a kind of benign disease, there is biological characteristic similar to tumour, closely related to ovarian cancer; Inner different disease causes menstruation of women of child-bearing age and infertile primary reason at present. "Inner different disease has illness coming on in the mechanism the complicated, shape with extensive pathological change has attacking and recuring nature variously and very much, a great deal of thorny problems are demanding prompt solution. " Executive chairman, BJ Union Hospital Professor Lang Jing of the meeting and saying in commenting the report.

In 1885, VonRokitansky described this disease for the first time. 1921, Sampson propose, plant theory by the intersection of blood and adverse current, become leading theory, have upper skin take, grow theory hereafter, distant place shift theory, Le Miao in charge of the intersection of remains and theory,etc., but not complete. Especially see to 90% of the women of child-bearing age by the adverse current of blood, it is nearly physiological phenomenon, but only 10%- 15% of the different disease while suffering from, so Sampson theory receives the query of the academia. In recent years, the scholars propose the function performed in different diseases inclusive of factor such as heredity, inflammation, immunity, hormone,etc. have illness coming on in succession. Since 2005, already enough evidence accumulated to publish the article had shown, the inner different disease was a epigenetics disease. In view of the above, our country utilizes histone acetylase inhibitor treats the uterus gland myopathically (similar inner different disease) Have made the gratifying preliminary result.

The intersection of meeting and executive chairman, the intersection of Shanghai Communications University and the intersection of medical college and the intersection of gynaecology and obstetrics and big to say grandson Guo, professor of research institute, the cause of disease of the inner different disease learns to be known as " The mystery " The same, comparatively a generally acknowledged one is a kind of hormone dependent disease at present, it is an amynologic disease, also someone is regarded as a kind of hereditary disease, or a kind of disease arising from environmental pollution. But the common points of these theories are that there is a large number of that express unusual gene in different diseases inclusive, and keep an unusual important mechanism of gene expression being that epigenetics is adjusted and controlled. So, study about epigenetics of the inner different disease, " mystery " that should be studied by the cause of disease of the different disease while revealing ,Develop the more effective medicine, offer thinking and means for diagnosis, prognosis and even new method of new technology to intervene.

Lang Jing and,etc. through organizations relevant pathology and molecule biological study,in not summarizing last " the trilogy " diseases different ,Stick, attack and blood vessel take shape, course this can explain and different the intersection of disease and clinical pathology behave describe, distinct, namely early red pathological change, model black pathological change and anaphase white pathological change. Lang Jing and pointing out at the same time, different persons (the different disease while suffering from or not suffering from) It go against ones that flow through at blood inner membrane for chip could in " The strange land " Stick, attack, grow, the difference of the inner membrane in place is a basic reason, and a decisive factor of different disease while happening.

Meeting executive chairman, subsidiary professor of hospital for obstetrics and gynecology of Fudan University points out Xu sword, have, study, brief on, on condition that exist by the adverse current of blood, have growth membrane come membrane in being on the throne totally either in the active malposition, may be split up by the stem cell of different sources.

Curative effect is still not fully up to expectations

The expert introduces, menstruation and becoming a thorny problem in the domestic and foreign clinic diagnosis job infertily that the inner different disease causes. Executive chairman, Zhejiang University medical college subsidiary professor of hospital for obstetrics and gynecology Zhang XinMei say the meeting, pain is characteristic symptom of the inner different disease, including menstruation, chronic pelvis pain etc., but pain of different disease is caused by any reasons on earth, still not totally clear at present. The expert introduces, a great deal of has different diseases inside Shanhaiguan that has illness coming on the hypothesis of the mechanism has not brought more effective treatment medicine, different disease medicine study and test and stop figthing cease to criticize or attack others finally in the overwhelming majority so far; Meanwhile, it is still not unified to appraise therapeutic in surgery method and curative effect to different disease in the deep department.

Meeting executive chairman, the intersection of Fudan University and subsidiary Liu, Professor of hospital for obstetrics and gynecology, say while cherishing, though inner different disease is a kind of benign disease, it is one of its characteristics to recur, it is a clinical and therapeutic difficult point at the same time. At present, inner different recurring of disease mechanism yet totally distinct, internal different disease recur further discussion of the mechanism, help guidance to treat, delay recuring, promoting and bearing. The appearance of the biological mark is to intervene the first step recuring, announce the biological mark thing participates in the biological route to recur, recurring of the different disease while helping to intervene effectively by a difference gene will express and duplicate the course to correcting. Professor of the People's Hospital of Peking University Cui Heng says, the protein group represented by protein two-way electric swimming, mass spectrum studies the development of technology, have offered the strong tool for finding the new molecule mark thing.

It is an extremely thorny problem appearing while treating too that the cancerating rate of inner different disease will be probably underestimated. Experts generally think, inner different disease having tumour characteristic. As far back as 1925, the different disease cancerated in Sampson was described at first, and put forward and judged that organized coming from the basis that the film was organized in the malposition in cancer. Cold beauty, Professor of BJ Union Hospital,etc. reports 1848 open belly or peritoneoscope there are 1.1% that amalgamate ovarian cancer in the inner different disease patient diagnosing it, but may destroy reasons such as inner different disease and juncture position focus tissue of the original hair,etc. because of the fact that the cancer tissue grows vigorously, the real data may be a little higher.

On the other hand, people find the situation of different disease is not rare either while amalgamating in the ovarian cancer patient. Different disease person is up to 20%- 40% while amalgamating in membrane one kind of cancers and transparent cell cancer patient in the ovarian uterus, therefore has proposed membrane malposition disease and relevant ovarian cancer (EAOC) in the uterus Concept. Age is smaller, one is not earlier, the prognosis is better that this kind of ovarian cancer patient usually has illness coming on. The ones that corresponded to it are inner different disease and relevant cancer and tumour (EOEAC) outside an ovary ,Take gland cancer as the core. Though this kind of case is very rare, usually have illness coming on after the different disease effecting a radical cure operation inclusive, cancerate and already with progress no longer depend on uterus and estrogen, it is extremely thorny to treat.

The expert participating in the conference thinks, because the morbidity of the inner different disease is high, influence life quality and working efficiency seriously, and it is costly to treat, patient's financial burden is heavy, have already become a serious public health problem, should cause and pay close attention to. The pathologic type of the inner different disease is various, clinical manifestation is complicated and changeable, have attacking and recuring nature very much, have latent energy of cancerating, difficult position of falling into when when the clinic diagnosis of making, become difficult disease that cure. Though the clinic diagnosis tactics of different disease, still face pain and sterile therapeutic effect not two good big problem while already setting up tentatively now; And inner different postoperative disease park high person who recur behind the medicine and problem that cancerate etc. demanding prompt solution. European Union has already increased the subsidy efforts of scientific research, the ones that are in the hope of the different disease inclusive make a diagnosis and give treatment the respect is broken through to some extent.

The expert participating in the conference proposes, the settlement of a great deal of clinical difficult problems of inner different disease, depend on further scientific research input, have illness coming on in the mechanism and may intervene the research of the route around launching the overall and deep inner different disease clinically, the research results will offer science and technology support for researching and developing new making a diagnosis means and treatment medicine.

Inner different disease is still disease difficult to cure