Wednesday, May 16, 2012

Pay close attention to the function of craning one's neck

Pay close attention to the function of craning one's neck to look into the distance of scientist of school's force
The intersection of Nobel and physiologic medical award of this year authorize in amynologic field making Boiter, Ruth of cloth, scientisting of American, that initiativing working, tying tight, French scientist Jules and Hoefman and Canadian scientist Ralph and Steinman, cite three immunologists " Find the inborn immunity activates the new mechanism " With " find tree dashing for ward form cells and function in the immunity of acquired character is replied " .

Three promise reward originality of winner work, announce inborn and the intersection of acquired character and immunity it replies to be how activate, its original discovery upgrades the amynologic theoretical research fundamentally, make people understand the morbidity mechanism of the relevant disease of immunity more deeply. The more important thing is, their research results are that the immunization therapy of disease especially vaccine design and application have put forward new theoretical foundation and technology system, to infection, cancer, immune diseases and inflammation one's own prevention and cure of diseases,etc. last Singapore side to, for routes new.

Three remarkable immunologists' award-winning is given too " A Nobel Prize for natural science " Our country scientific and technological circle and scholars last much thinking and enlightenment. Proceeding from scientist individual angle, I put forward the humble opinion from six following respects, please make a comment.

1.The original sexology thought of scientist of master's force: Three immunologists' initiative spirit is praised in the international immune educational circles extensively, the reason why they have made the revolutionary originality scientific discovery and upgraded modern amynologic basic theories separately, because they have reached a kind of realm from the essential understanding to scientific research in the heart of hearts, namely" speech people have not spoken, seen people not meet " . The so-called master's scientist of grade refers to standing in the front of discipline, condensed and fundamental great important science problem, opens up the new research field, or in a certain key sexology problem of a certain domain pertinence settlement, have remarkable contribution, lead to can lead scientist that field advance with visual field of internationalization constantly this the intersection of discipline development and Singapore side. This kind of scientist is the creative talent of high level walking in the international front all the time, they have strong initiative spirit, innovative consciousness, have very strong innovative ability.

2.The first-class scientist's originality technology system: Because should solve the critical scientific problem, have to set up the technology system of originality to solve the difficult problem met while studying by oneself sometimes. The setting-up of the technology system can even promote the development of whole field, can expedite the emergence of the new academic thought too. Three award-winning immunologists have one's own originality technology systems this year: Fruit bat and congenital immunity of Jules and Hoefman study the system, the little mouse of sudden change that cloth Ruth and Boiter tied tight induces system and biological function to screen the system, the tree of Ralph and Steinman dashes for ward form cell training, determining, immunological function and analyzes the technology system, these systems generate a key impact on their own primitive innovative scientific research, the study on latecomer or follower has played the important function of technical support too after popularizing and applying.

3.The leading scientist's function of craning one's neck to look into the distance: I have ever listened to three immunologists' excellent report at the international conference many times, the speech of their operating from a strategically advantageous position type, especially to analysis and thinking of the critical front line science question of future in this field, and the clear prospect of discipline development trend makes conferees subdue. The more important thing is, three immunologists and laboratories have issued studying the thesis of important meaning all the time on the basis of finding originally, expand depth and broadness studied constantly, a lot of theses become programmatic literature that the researchers of this field read and understood repeatedly. Three immunologists have issued summarizing in the world first-class magazine ' Among them the number of times of quotation that the tree which Ralph and Steinman issued in Nature dashes for ward form cells and summarizes is up to for more than 4000 times) ,Having pointed out the direction for the development that this field is next, have played the function of craning one's neck to look into the distance.

4.School grades of human resource development and scientist's colony of scientist gather consciousness: We referred to the impetus to scientific development of the school less than in the past at present, in fact, review the scientific and technological history of the world, a lot of proposition and completion of great scientific discovery and scientific theoretical system are related to scientific school.

The scientific school, as a kind of ripe scientific research organization or learned society, based on judgment and gain experience, appear and assemble, form together to have on some research fields and some scientific problems originality, often in leading position, taking as the leading factor and scientist's colony of scientist who enjoys lofty prestige to make up. The scientific school has dominated the direction of a certain field development to a certain extent, especially opening up the frontier of discipline development, propose field develop Singapore side to, the respect has played a positive role to make breakthrough progress on constructing the new theory of the new view, promoting the research of basic scientific theory and front problem of the great science finally.

Three award-winners are with Steinman " The qualification is the oldest " ,It establishes " The tree dashes for ward cell International studies of the form " Hold once every two years each time ' Held in Switzerland on the 13th last year) ,Participate in several dozen initial people to the conferees of about 1500 people of nearly several, has indicated it is prosperous day by day under the leadership of Professor Steinman that the tree dashes for ward the cell field of the form. I joined the seventh tree held in Pittsburgh of U.S.A. and dashed for ward cell International studies of the form in 1998, join seven seminar continuously already so far ' Have been invited to make the conference to report at latest the second meeting) ,Each meeting conferee greatest enjoying is listening to Steinman's summing-up speech on the closing ceremony, that kind of current situation and development trend analysis and demeanour of a well-bred girl of looking forward to in the future to this area research as if enumerating one's family valuables, have influenced numerous scholars deeply.

Professor Steinman pays much attention to guiding and supporting the young scholar, his first doctor MichelC.Nussenzweig is a chief of the office of the amynologic experiment of molecule of Rockefeller university at present, elected academician of American Academy of Sciences this year. In addition, the students who Professor Steinman trained spread all over Japan, Germany, France, Britain, these students have made the world-class tree to dash for ward the cell research work of the form in this country, or dash for ward the form cell tumour seedling on the tree to apply to the clinical trial, and made the prominent result, thus push tree dash for ward the intersection of form and the intersection of cell and the globalized development of field.

What deserves to be mentioned is, three immunologists have trained Chinese students, for example, from Wuhan University Liu's health is Steinman's doctor, have issued several trees to dash for ward the cell thesis of the form in the world first-class magazine. Hoefman pays attention to the academic exchange with China very much ' Once visited the academy of sciences of Shanghai life of Chinese Academy of Sciences for several times) ,Shanghai insect researcher, news of plum, Cao ever work in their laboratories. Xiamen University biomedical the intersection of research institute and Professor, the Huaihe River of house, Han and the intersection of Beijing and university student order the intersection of academy of sciences and Jiang strive all to teach? Tease and send Put down a difficult of Ji and cough and deceive Put down Ji put on cangue Fu slightly Wei stops Outside Hua's C NS thesis, two have published the thesis in Science, NatureImmunology separately after coming back home to establish one's own laboratory, " there are no poor soldiers under a good general " to show ,Also indicate the future of life sciences of our country is promising.

5.Successful toughness character and psychology willing to be lonely that the remarkable scholar grows up: The winner is often full of hardships and helpless at the beginning of starting an undertaking behind being vivid and superficial, revolutionary scientific discovery to the scholar who has the original academic view, the educational circles often can't be snapped up, so, need tenacious character to think the work that is a truth perseveres oneself. Nowadays is recognized as by everybody " The tree dashes for ward the father of form cells " Steinman find by tree to last form cell and propose independently whether there are after a cells immunes new on this at 1973, because it is innovative and too strong, was not admitted by the academia at that time, that he insisted on have been studied for nearly 20 years, until the 1990s of last century, the immune educational circles really realized trees dashed for ward the importance and and meaning of the clinical disease in the immune system of form cell, relevant trees dash for ward foundation and clinical research of form cells just the prosperity stand up in the world, from the viewpoint of this angle, Steinman is that one has tough and tensile character and pioneering scientist moving ahead in the loneliness. The ones that reviewed domestic scholar and educational circles are eager for quick success, have to review my national calamity in order to train or scientific research environment and culture atmosphere of the world-class scientist emerge independently.

6.The outstanding biological physician often pays attention to actual application meaning and potential value of the basic research results: Except the purpose of the biomedical research meets the scientist's curiosity and scientific basic law of exploration, the most important purpose is to serve human healthy and high-quality life and environment, so, a lot of outstanding scientists' research is for the basic science problem (birth and old age,sickness and death) in the biomedical field at the beginning And the one that launch.

A common characteristic of three immunologists' is that their basic research results can guide the practical application of prevention and cure of disease, because they in inborn and how immunity activate acquired character and how accurate to adjust and control the intersection of mechanism and discovery of, amynologic basic theories have development of concept nature, have promoted the practical application of immunization therapy of disease greatly.

Typical example analyze the intersection of oneself and the intersection of tumour and type of antigen actively after diagnosing as pancreas cancer Steinman and the intersection of application and one's own tree dash for ward form cell prepare the intersection of tumour and Miao Used in oneself treatment, make its condition control and survive for more than 4 years for a time. U.S.A. FDA sanctioned the first cell immunization therapy medicine in the world last year: A is used in the vaccine (Provenge) curing prostate cancer ,It is that patient one's own tree dashes for ward the therapeutic tumour seedling prepared of form cells in essence, the great break-through of such international pharmacy circle is undoubtedly based on Steinman's basic research results.

Boiter ties and Hoefman's research on discerning the molecular mechanism in congenital immunity tight, except that infective disease, one's own immune diseases and inflammation diseases,etc. had illness coming on the exploration of the mechanism has opened up the new research direction, also offered the target of potential medicine for prevention and cure of these diseases. A lot of enterprises and new medicines research and develop the organization to put into a large amount of manpower and materials in this field at present, the purpose is to hope to find the medicine used for prevention and cure of disease. Therefore the importance and studying the brightness prospect combined of the utility of basic research and prevention and cure of disease of the basic research.

If scholars of our country can combine the abundant clinical resources in our country, to endangering human health especially some great great prevention and cure of disease of our country's high taking place and harmfulness, launch the innovative biomedical basic research and pay close attention to the fact the utility transformation is studied at the same time, after some time, believe under the great background that the country is advancing the reform of scientific and technological system constantly, the biomedical research of our country will emerge the first-class achievement which world admits definitely, also therefore the first-class scientist with international academic influence emerges in the native country of China.

Pay close attention to the function of craning one's neck to look into the distance of scientist of school's force

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