Origin that it is the epilepsy that the excitatory synapse

Origin that it is the epilepsy that the excitatory synapse function is strengthened to break out repeatedly
It is reported ' Reporter Kuang YuanShen) Subsidiary God Temple Hospital, researcher of Institute of Neurosurgery of Beijing Qiao Hui, grandson's different forest of Beijing of Capital University of Medical Sciences,etc., find through studying the ultra micro-structure of pathology with focal epilepsy, the image has not had pathologic change at various degrees in the unusual temporal lobe epilepsy patient's brain tissue and sea horse to learn to check, especially responsible for the excitatory synapse of information transmission, enhancement of its function in the brain, origin of causing electric physiological function of epilepsy patient's brain unusually and spontaneous outbreak with repeated epilepsy. This research had illness coming on for the epilepsy the mechanism has offered the new view.

The epilepsy of temporal lobe is also called the movable epilepsy of spirit, it is dept. of neurology and common disease, the morbidity in our country is about 7%. . Most views think, it is a main cause of disease which initiates the epilepsy of temporal lobe to harden inside the temporal lobe at present.

Qiao choose 7 God Temple Hospital diagnose awkward person who manage, CT or the intersection of core and magnetic image learn, check, have unusual temporal lobe epilepsy as the research object already by Hui, the intersection of grandson and different forest,etc., the intersection of course of disease and 2, 10 year 4, 20 year more than one in 20 year from 5 year to 10 year, make electroencephalogram or 24-hour video brain electricity to monitor in front of the skill among them. In the skill, fetch the cerebral cortex sour jujube wave cooking stove of temporal lobe and electric mirror that makes the ultra micro-structure of hippocampal tissue to observe under the circumstances that the electricity of brain is monitored. Found finally, 7 patient's electric physiology were checked and can be seen typical Xian kind and discharge. Can see cells and arrange the level in cortex sour jujube wave cooking stove and sea horse of temporal lobe unclearly, interreaction is disorderly, the neuronal sex change is firm to contract, the interval is diminished, some neuronal density changes. Among the cases observed, it changes that nearly all nerve touches the quantity suddenly and touches the structure suddenly, excitatory synapse obviously increases, but the inhibiting from is touched and obviously reduced suddenly, the blood brain protective screen is destroyed.

The grandson thinks, the above-mentioned pathology that the neural image learns to check temporal lobe epilepsy patient not seeing the sea horse harden changes in the different forest, especially the change that the nerve touched suddenly, has broken epilepsy patient's excitability and inhibiting equilibrium of mechanisms in the brain of temporal lobe, and form Xian making the epilepsy initial and neuronal and discharge in the excitement cycle which must use the intensification repeatedly, the ones that produced and unusually discharged were conducted remotely, thus has caused the repeated spontaneous outbreak of the epilepsy.



Origin that it is the epilepsy that the excitatory synapse function is strengthened to break out repeatedly