The law of mercury ion is paid close attention to

The law of mercury ion is paid close attention to by the world counterpart avoiding marks to measure in water more than the color
It is reported the scientific president's academician of Chinese Academy of Sciences of key laboratory of electric analytical chemistry of research institute of applied chemistry in spring in China is deep and vast the health seminar innovates out mercury ion (Hg2 +) Four extremely sub the intersection of DNAzyme and used for measuring mercury ion than the color method that regulate, relevant to work on 2009 publishing in magazine, " analytical chemistry " of U.S.A.. The reporter, from should learn, after this thesis is issued, are paid close attention to by world-wide counterparting recently, become, carry on whom mercury ion measure with core with four extremely sub DNAzyme must the quoted passage is offered.

This article is still appraised as one hundred most influential international scientific papers of China of 2009.

Mercury ion is a kind of heavy metal pollutant in the water environment, toxicity is high, damage human health, so, monitor in the water environment in a more cost-effective manner the voice that mercury pollutes is higher and higher. For this reason, people have developed a lot of high and sensitive, highly selectively sensors of mercury ion, a hot one with containing T base to gather core to be sour as sense the component, come on and sense and analyze mercury ion in the ink while being widowed among them. Study to reveal, it is right and two T bases that mercury ion can be combined in DNA two strands form the steady T-Hg2 + - T base, can induce DNA to turn into and construct the phenomenon, this utilizes DNA including T to analyze that measure the basic operation principle of mercury ion. In most cases, generally need to mark, decorate DNA and sense the component with particular indicator such as fluorogenic group, this will no doubt bring a lot of advantages, but the experiment cost is relatively high. By contrast, the detection method which avoids the mark does not need marks / modify the step, therefore is comparatively simple and convenient, economic.

Deep and vast the health seminar passes the peculiar function between T base which utilizes mercury ion and AGRO100, to regulate its DNAzyme activity, thus has developed a and measured the simple and convenient method to avoid the mark of mercury ion in water more than the color. Because mercury ion binds with T base in four extremely sub DNAzyme and forms T-Hg2 + - T base right, make it can't fold normally, thus has inhibited its DNAzyme activity, this all right use ABTS-H2O2 reaction system is paid and monitored. Have no mark than the color method through this kind, can measure to 50nM (namely 10ppb) Mercury ion,under it is at pharmaceutical of shielding for the aids of the PDCAs,be alternatives better mercury ion analytical methodded.

In addition, even if another meaning of this research work has proved even a small amount of mercury ion possesses the ability to destroy four extremely sub structure, and four extremely sub structure in human terminal mitochondria ' Telomere DNA) Find, this is understanding that the mankind's poison has offered newly of mercury ion.

(the stone bright mountain of Yu Yang)

The law of mercury ion is paid close attention to by the world counterpart avoiding marks to measure in water more than the color