The global scientist orders to arrest the mysterious germ

The global scientist orders to arrest the mysterious germ Chinese detective draws a portrait for the European killer
Peasants are suffering tens of millions of losses of European dollar, have not piled up into a mountain vegetables and fruit eating, 798 people's life is in imminent danger If uncovering the arch-criminal, this largest epidemic situation of relevant type of Escherichia coli in modern history, it is difficult to imagine what kind of consequence will also be initiated.

Since mid-May, a kind of rare Escherichia coli mutation has spread from Germany to the whole Europe. This is regarded as at first " Enterorrhagia Escherichia coli " (EHEC) Killer,lead to the fact symptom it appear patient on abdominal pain, diarrhoea, having a fever and vomiting, the serious one will develop into and dissolve hematuria and poisonous syndrome, jeopardize the life.

Because originally mistake epidemic situation source for vegetables fruits such as the cucumber, tomato,etc., the Europeans who love the salad have to hesitate when the romaine lettuce, this causes innocent vegetable grower to suffer heavy losses; On the other hand, the epidemic situation has caused the jitters of the international relations, the beginning of this month, Russia claims to forbid importing the fresh vegetables from all countries of European Union, has caused European Union to protest strongly.

When people can find no way out to the nameless killer, the Chinese scientist but during when only three days, sketch the contours of its appearance and offence characteristic, and offer the method to judge the criminal fast.

On June 2, the large genetic research institute and Hamburg, Germany - one angstrom of general many medical centers of university of China of Shenzhen jointly announce, the analysis on the whole genome array of germ reveals, caused recently the intestinal disease in Germany was infected with the germ of the epidemic situation was a kind of new pathogenic Escherichia coli which attacked, produced poison and enterorrhagia,etc. characteristiced.

"This cooperation with China is very accidental, but our favorable turn - -Our luck has arrived. " German Hamburg - doctors of medicine of one angstrom of the Peng 's, participate in the intersection of German and the intersection of Escherichia coli and the intersection of epidemic situation and the intersection of Moritz and henries of Cheickh, member of research, of research group this say when being interviewed by China Youth News.

Germany uses " Input, unusually high-efficient of the whole feeling, ability is superior, the speed is surprising " To describe the Chinese cooperative partner

The old lady 83 years old who guides general Holts begins to attack one to come from the city of the north of Germany since May 15, the killer wreaks havoc by the speed of making people difficult to imagine. According to World Health Organization (WHO) The information offered recently, the epidemic situation spreads to include 11 countries of Europe such as France, Britain, Spain, even go abroad to U.S.A..

One hertz of epidemic situations that research institute announces on June 17 of Robert department that Germany is responsible for controlling the national epidemic situation notifies that reveals, the killer with fuzzy this appearance captured 38 people's life during more than one month, causing 3408 people to infect, 798 people among them develop into and dissolve courageous and upright urine poisonous syndrome, the life is in imminent danger.

Escherichia coli is normal component of group of the human intestinal fungus, under normal conditions not endanger the mankind. But some mutations such as enterorrhagia Escherichia coli, will cause serious disease. In all parts of the world, there are appearances of Escherichia coli case of enterorrhagia nature every year, sometimes will dissolve courageous and upright urine poisonous syndrome even the case dies too, it is far lower than this German epidemic situation but influence.

Perhaps, appearance of killer let Germany make no adequate defense, participate in the intersection of Germany and Hamburg - angstroms of many the intersection of and the intersection of university and Rod, Professor of medical college, Peng of research this especially. As the bacterium expert, he finds different from traditional " enterorrhagia Escherichia coli " The case, this kind of germ will also attack the patient's nerve, leads to the fact the patient presents languages to express obstacle, forgetful, serious epilepsy even symptom going into a coma. In addition, the patient is mainly the adult over 20, especially women, but not the common children in the past case.

When Rod is that a burst of epidemic situation is badly battered busy, he meet, go on business just graduate student of Chinese post-doctor Yang that come back on in restaurant.

This Chinese student contacting the gene order-checking matters, has made suggestion for the tutor: Contact the big genetic research institute of China of China to do gene order-checking, this research institution is not merely the biggest genetic sequencing and research center in the world, and just got on horse in the newest order-checking platform.

"We hear the intersection of China and old gene, know it whether one have very strong the intersection of research and ability and enrich organization to study experience in gene order-checking, but until Yang bright suggest, all of us had not really considered cooperation yet. " Henry of Cheickh says.

Development of transnational this of cooperating. On May 30, the sample that has typicality most that Germany chooses is expressed to Shenzhen. "Our setting about to check order at once and data analysis after receiving samples. " Big genetic spokesman of research institute Yang BiCheng in China Shenzhen China introduces to China Youth News. About a dozen, 25 -year-old genetic researcher Hua Da of mean age have participated in this research.

"Everybody regards this thing as the first PRI, will often stay up to study until the next morning, have not even had a holiday on the Dragon Boat Festival. " Participate in researcher Li JunHua among them and say, " this thing is very important, can't even stop over in one quarter. "

Such fast reaction mechanism, let one of Spain responsible for, carry on automatic the intersection of researcher and the intersection of Marina and graceful auspicious Kui that biological information firm work of analysis praise to the intersection of killer and the intersection of genome and array this again and again. She comments when being interviewed by China Youth News: "One of China's great advantages lies in, even if contact them on weekend, can be replied rapidly. The await orders at any time reply, correlated with, work to epidemic situation essential while being high-efficient. "

Germany to praise, have, add too to cooperation this time. Henry of Cheickh describes this Chinese cooperative partner with four words - -" input, unusually high-efficient of the whole feeling, ability is superior, the speed is surprising " .

"All exceed my expectation, for me, this is a pleasant surprise. " Rod says.

" genome atlas of Zongzi edition " Reveal the killer's past completely

After finishing gene order-checking and data analysis, the big genetic research institute of China has upgraded the array atlas of a copy of genome, this means accessing the killer's file, has revealed the other side's past completely. This is issued in the atlas on Dragon Boat Festival, is called for fun " genome atlas of editions of Zongzi " .

The big genetic research institute of China still develops diagnosing reagent box. Use this kind of method, can shorten the detection procedure of two or three days of the need as two three hour, this is all right " Offer support for that the condition diagnosis in the global range, epidemic situation monitor investigating with the pollution sources " .

" genome atlas of Zongzi edition " Have shown all criminal records of the killer's: Kinds of germ combine two kinds of genes pathogenics in? Ape's 's Spanish mackerel's interconnected system of Hui department of 's source of yellow Lu Nao Feng's salty quiet 's stupid vinegar Is called Hui department of the source? EAEC) Pathogenic gene.

As the lethal weapon of first of the killer's, enterorrhagia Escherichia coli attacks the erythrocyte in the blood, cause the erythrocyte to dissolve, the blood capillary to block etc., will cause acute renal failure. Another big lethal weapon intestines sticking Escherichia coli helps germs to adhere to intestines cells, thus enable it to occupy in the inner constellation of intestine for a longer time, has lengthened the time to attack the erythrocyte, cause greater destruction.

"The combination of the two may cause this germ to have such strong aggressiveness. " Henry of Cheickh says. In view of this, the German brother researchers of the court root university propose renaming the killer as " the intestines gather sticking Escherichia coli " .

The more terrible one is, it also has intrepid defence capability. It is right and including spore's fungus is plain, penicillin and Streptomycin antibiotic to be able to bear the medicine gene that it contains, will cause some antibiotic to fail to respond to any medical treatment. "It has both lance and shields, the release virulence that can use the virulence gene to go on one hand, in addition it has antibiotic to the medicine defensive on one hand, can carry on some protection to oneself. " Yang blue and clear to explain.

However, as to the pathogenic mechanism of the pathogenic gene such as how it is releases the toxin out, and how to go control it, need more experiments and research.

Perhaps this will be looked for and broken through from the killer's ancestor one. According to " genome atlas of Zongzi edition " Analysis,the 2001 one Europe last probably the killer the ancestors lineals of germs. The reason why this killer has such strong ability nowadays, perhaps because through the evolution of 10 years, having obtained some new genes, thus have ability able to bear many more kinds of antibiotic.

"Gene order-checking and data analysis help us to further define, what genes are the essential gene causing enterorrhagia Escherichia coli, also contribute to finding out about the development situation of the germ, also developing vaccine to us offers help. The research will help the pointed healing solution will happen finally to us. " Henry of Cheickh says.

Scientific research workers in the whole world study the same germ together for the first time

This is not that research China of epidemic situation worldwide of the first time of Chinese scientist contributes. Serious acute respiratory tract syndrome (SARS) that broke out in 2003 In the epidemic situation, the big genetic research institute of China has participated in gene order-checking too, and develop and pay a home visit to break reagent box quickly. But SARS just works out the valid antibody after three or four months, young Chinese scientific research personnel " race against time " this time ,Hope to capture the manor ahead of killer.

"When the epidemic situation breaks out, time is the most important. " Yang BiCheng says. After Chinese scientific research workers find the genome atlas of killer's germ, " the first thing that expects is to announce to at once that on net " .

This is exactly another magic weapon of dealing with the killer - -Cooperation. After the Chinese scientist obtains the genome array, use Facebook, Twitter, blog,etc. to link up the means and seek the killer's origin and reply with scientific research worker in whole world immediately.

Henry of Cheickh thinks it is qualified international cooperation that the gene order-checking this time is studied, "Germany offers samples, China has finished checking order at the surprising speed, after getting the genome array, the researchers of countries such as China, Germany, France,etc. understand and analyze the data. " Science publish article in latest one too, recommend global scientist study pathogenic the intersection of Escherichia coli and the intersection of germ and the intersection of genome and course of array together, among them has especially referred to the high-efficient work of the Chinese scientist.

"This should be that a scientific research worker in the whole world study the same germ together for the first time. " Yang BiCheng says.

"We appreciate China's great one point lies in, they have announced the array initial data of the genome as soon as possible most, any organization does not does so before this. Share the great information of this value with all people, China is the first. Up till now, the intersection of China and loud gene announce all initial data to the outside only too. " Graceful auspicious Kui says.

Already there were obvious slowing down signs in Germany's epidemic situation recently, the ill number of people was reduced by a wide margin. According to the announcement that Chinese Ministry of Public Health released newly, though China exchanges people-to-people contacts with foreign countries frequently, the risk taking place in inputting epidemic situation of the existence, but up to now, there has not been case report within the territory of China.

However, the situation still allows of no optimist. According to the information announcement on June 20, enterorrhagia Escherichia coli may have already entered surrounding environment such as the river through the infeted's excrement, investigator test the pathogen one has produced in the intersection of state and one brook, Hessen of Germany, and already been verified the situation propagated that there is human, this may bring greater crisis.

To the healthy policemen who seizes killer's germ, perhaps the precedent of SARS can offer enlightenment. "Present situation and SARS epidemic situation have much similarity, for example can't totally confirm that infect the source, not have vaccine and therapeutic method at the moment. " Henry of Cheickh says, " has not still treated the method of SARS effectively by today, but the epidemic situation has already depended on the means of sterilizing, isolating etc. can be contained. Perhaps German Escherichia coli epidemic situation can pass country and hygiene officer prompt coordination and intervention too, prevent the diffusion of the epidemic situation in case of not having the healing solution. " (intern Lee marked)

The global scientist orders to arrest the mysterious germ Chinese detective draws a portrait for the European killer