Crohn's relevant gene of disease influences the immune cell function

Crohn's relevant gene of disease influences the immune cell function of intestine
Author: Mei Jin

It is reported American scientist report claim related to Crohn's disease gene a certain will influence a certain the intersection of intestine and immune the intersection of cell and health status that take specially recently. This discovery will help the scientist to develop and treat Crohn's new tactics of the disease. The relevant thesis will be published on Nature soon.

Crohn's disease is also called segment ileitis, it is one of the most common hereditary intestines problems, its symptom including diarrhoea, belly is pained, vomited and the weight is lightened. This disease will probably cause some or complete intestinal obstruction, thus have to carry on the surgery treatment.

The finding before this, some Crohn, mutation will take place in the disease patient's Atg16L1 gene, this sudden change will increase and suffer from Crohn's risk of the disease, but does not cause Crohn's disease automatically.

In the latest research, KenCadwell and colleague of American Washington University School of Medicine utilize the hereditary means to transform the little mouse, make its ability to make Atg16L1 albumen become weak. Found finally, the reduction of Atg16L1 albumen was to Paneth cells (the immune cells in small intestine) Have prominent influence. Cadwell says: "When Atg16L1 becomes less, Paneth cells can be stored and lived on, but they secrete the antibacterialing ability of amino acid particle of contracting and are obviously weakened. "

In the further experiment, researchers strike except little mouse's relevant gene that another one is called Atg5 in the body, Atg5 can promote biting function by oneself of cells. Found finally, Paneth cell function in this little mouse's body was damaged too, this indicates Atg16L1 promotion of Paneth cells may be with biting function to have something to do with by oneself.

Thesis senior author, pathology of University of Washington and amynologic dean HerbertW.Virgin are said: "We do not still know why abnormal Paneth cells will make people apt to suffer from Crohn's disease at present, and the other genes related to Crohn's disease are influencing Paneth cells on any intensity. But these are exactly derived interesting and was worth problem going into seriously of research once from then on. "

Crohn's relevant gene of disease influences the immune cell function of intestine