Clone animal's birth rate to improve by 6 times

Clone animal's birth rate to improve by 6 times
It is reported ' RuiZhe Wang Chun Xu) In the past, it has very low to clone the efficiency that embryos succeeded in developing into the new individual all the time. On April 8, issued an item of newest scientific findings of Shanhai for the internationally famous academic periodical " cell stem cell " - -The scientist has proved conclusively that clones the key reason why embryo's development fails, and then pass and repair the defect among them, make the birth rate of cloning animals improve by 6 times.

Regard cloning the little mouse experiment as example, have 50% to 70% " nuclear to transplant and reconstruct embryos " Can become the blastaea in little external development of mouse, but move these blastaeas in the little mouse uterus, but only about 3% of blastaeas can develop and clone mice. It becomes individuals that it can't be developmental why does the majority clones the blastaea, a kind of hypothesis thinks in the world, because this is because of cloning it in the nutriment ectoderm of the blastaea, have a kind of " unusual cell of heavy programming " . However, this hypothesis has not been verified directly all the time.

Chinese Academy of Sciences Shanghai grow department institute biochemistry and cell the intersection of strength and loose seminar Li go on, prove directly to the hypothesis, have verified those unusual cells really clone the key reason why embryo's development fails. Seminar member Lin JiangWei,et al. has adopted one kind to known as " Embryo compensates the tetraploidy" Auxiliary reproduction technology ( This technology is usually used for failing in development of saving the placenta development defect and foetus causing it) ,All replace cloning the ectodermic cells of nutriment of the blastaea into tetraploidy cells, found finally that cloning the birth rate of the animal therefore could improve the amount of time 6.

Researcher Li JinSong thinks, the nuclear transplantation research field in life sciences of this result of study enlightens meanings, also offered the theoretical foundation for raising animals and cloning efficiency and nuclear transplantation technology and is used in the health field of population. This job has got the funds support of Ministry of Science and Technology, national natural fund committee, Chinese Academy of Sciences and Shanghai State Scientific and Technological Commission.

Clone animal's birth rate to improve by 6 times