" The albumen scalpel " Cut the genetic fragment accurately

" The albumen scalpel " Cut the genetic fragment accurately Help and research and develop the new treatment
A kind of hybridization albumen can judge and compile the genetic part as required

Expected chromosome used for improving the plant, animal even human

According to scientific August 30 of association for promotion of U.S.A., U.S.A. likes carrying on one's shoulder or back China's state university researchers and researching and developing a kind of hybridization protein, it can make double-stranded DNA under living cell ' DNA) Rupture in the position that needs, and can insert the function genetic fragment needed. This achievement is expected to bring better individualized gene therapy.

Hereditary development and Yang Bing, biological associate professor of cell, ' Transliteration) And the group splices the proteins of two kinds of different bacteria together, develop this kind of hybridization protein. A kind of protein calling type duplicates and activates albumens(transcriptionactivator-like, is abbreviated as TAL) The effect device, it is responsible for looking for the location that needs cutting off to click; Another kind of protein is nuclease, in order to cut off DNA chain, so should hybridize albumens and is called TAL effect device nuclease.

Cut away the defective or unwanted DNA part, substitutes with DNA function passage, this course is called the homology to recombinate. The operation principle of hybridizing protein is, kind duplicates and activates albumens to read DNA array first, look for the particular location that needs to cut off to click, and some is connected with DNA in this particular location, and then the nuclease albumen part will cut off DNA two strands in the junction, thus remove the defective bit of DNA, insert new DNA parts needed.

Liked reaching five to demonstrate TAL effect device to carry on one's shoulder or back the plant pathological associate professor Adam and Bogg of state university of China one year ago, insert a kind of special DNA array in the genetic fragment very simply. See Yang Bing that should demonstrate according to this inference, TAL effect device nuclease can be bound with DNA and cut off it, and start this research work immediately.

Yang Bing says, can set up arbitrarily according to different needs while hybridizing protein, thus realize and find out the particular location to click in DNA of any organic organization. TAL effect device nuclease has improved the present transgenic tool, and cost lower speed is faster, it is easier too while discerning the particular DNA array. This break-through is all effective to many kinds of organisms, it is expected to be used for improving plant, animal even human chromosome group. (often beautiful monarch)


" The albumen scalpel " Cut the genetic fragment accurately Help and research and develop the new treatment