The immunity is tolerated to transplant and study family's earnest

The immunity is tolerated to transplant and study family's earnest focus

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It is reported ' Reporter Li Ying) And transplant the international collaborative project of the largest scale of the field as the organ donation of our country, "centre of international exchange and cooperation of Ministry of Public Health- Promise Chinese and environmental foundation's China's organ donation and transplanting the collaborative project " Held the ninth scientific seminar a few days ago. This seminar has attracted over one hundred domestic liver renal transplantation scholars, and support the body shortage problem to what the domain of domestic organ transplant at present faces, immune inhibitor used and has been improved and transplanted and paid exchanging by the topic of surviving for a long time etc. person rationally after donating progress for pilot work for organ transplant, transplanting in China's heart death.

The organs transplantation of our country started in the sixties of the 20th century, the total quantity of annual organ transplant was reached about 10,000 cases at present, second only to U.S.A., rank the second in the world. 2010, China heart transplant with lung dirty to transplant, register the system, run formally even. So far, register the system, register the liver, transplant 19640, kidney, transplant 50391, 396 cases of heart transplant and lung is dirty transplant 74. Meanwhile, it is sure to break through that the basic research of organ transplant has been obtained too, and begin to apply to clinic. Regulating T cell, tree dash for ward the immune induction that tolerated after biological characteristic and research of the molecular mechanism of transplanting immune cell have been promoted and transplanted of form cell; Living and examining and puncturing the pathology of examining etc. alive with the zero point fast studies and raises accuracy rate of diagnosis of the rejection and therapeutic effect. Foundation, with combine closely while being clinical, to transform while being clinical, transform medical science promote steady development of organ transplant scientific findings.

Chinese Medical Association the intersection of organ transplant and credit can Vice Chairman, the intersection of CPLA 309 Hospital and the intersection of entire PLA and the intersection of organ transplant and the intersection of centre and the intersection of stone and bright firm professor introduce, it has been focuses of transplanting immunology and studying all the time that T cells activated and implanted the rejection, it is to implant the key link of the rejection that the ones that think T cell activation, cell factor are produced. But in recent years, people have realized the equilibrium relation between regulating T cell and effect T cell more and more. Regulating T cell CD4 +CD25 +FoxP3 +Treg is inferior group of T cell with immune regulating function, it induces and keeps the immunity being able to bear being effected by respect after transplantation but paid attention to more and more by people.

Under the inspiration of regulating T cells, people find some immune cells that originally played a positive role while the immunity reply successively, namely B cells, DC cells and NK cells have immune regulating function at various degrees, named as regulating B cell, regulating DC and regulating NK separately. Organ transplant experiment and discovering clinically, these regulating immune cells have inhibitory activity at various degrees in implanting the rejection, keep ability that the organism opposes disease at the same time. Under the existing condition, optimize the immunity and inhibit the healing solution from maximizing a patient and benefiting in respects such as curative effect, security and surviving for a long time,etc.. In addition, adjust the phosphatase inhibitor medicine (CNI medicine) as to calcium ,More large-scale and long-term data reveal the ring spore usually has better evidence of surviving for a long time, especially suitable for use in the patient of the high diabetic risk. These individuals' research of optimizing the scheme is the direction which the clinician explores actively at present too.

The immunity is tolerated to transplant and study family's earnest focus