The cause of disease of congenital heart disease is found

The cause of disease of congenital heart disease is found
It is reported ' Reporter Li TianShu) A few days ago, the nutrition of academy of sciences of Shanghai life of Chinese Academy of Sciences is scientific research institute and the researchers of the medical college of the university of Indiana state of U.S.A., Walther cancer research institute are united, have announced the relation between Smad7 and congenital heart disease for the first time in research of congenital heart disease. Research results this publish at " the biological The Chemicals ".

Smad7 adjusts and controls a key protein in TGF-beta signal thorough fare, split up in cell by TGF-beta, immune adjustment, organize fiber take and embryo development,etc. play an important role in the the intersection of life and activity early period. The expression that all have Smad7 in human many kinds of diseases is unusual, but the researcher is not very clear to the concrete relation between Smad7 and disease.

Researchers such as the scientific research institute Chen Yan of the nutrition of Chinese Academy of Sciences,etc. have set up a Smad7 gene to strike and get rid of the little mouse model for the first time, found finally it could cause abnormal development of little mouse's embryo's heart that Smad7 function was lacked, the little mouse heart presents ventricular septal defect, aorta and lung artery to shift, the myocardium shape is unusual. Strike in a few Smad7 genes surviving except that in the little adult mouse, it is disorderly, arrhythmic, etc to present the heart function.

This research results have announced the relation between Smad7 and congenital heart disease for the first time, have pointed out Smad7 closely related to animal heart development and heart function.



The cause of disease of congenital heart disease is found