Study and obtain great progress in meticulous adjustment of immune

Study and obtain great progress in meticulous adjustment of immune system
It is reported in the research institute the second army medical university is amynologic, medical immunology national key experiment chief of the office academician Cao XueTao and seminar which brilliant work associate professor, Dr. Hou Jin,etc. Ann make up, have found immune cells in cases the pathogen is stimulated and infected with with the virus, produce interferon and new adjustment mechanism of the inflammation cell factor. A few days ago, thesis of this research and published a concerted forms in which special topics commented to publish on " natural immunology " magazine with front cover title.

Macrophages and the tree dashed for ward form cells and belonged to immune system " Sentry " --The antigen offers cells, its function can discern that invade the original body of venereal disease of other source of the organism and engulf and eliminate, and activate the immunity to reply in order to remove the pathogen. If damage that can cause the organism to organize out of control of this kind of cell, even will bring out the immune disease of inflammation oneself and take place. So, the response course of this immune cell is certainly finely adjusted and controlled.

Cao XueTao,etc. is under study for action, observe the little mouse of phosphatase SHP1 genetic defect can produce a large number of inflammation cell factors and follow the emergence of inflammation one's own immune disease such as arthritis, find genetic the intersection of defect and little mouse this it is difficult that interferon emerges in a situation that the pathogen stimulates and the virus is infected with. This suggestion, the immune system adjusts and controls route and mechanism that interferon and inflammation cell factor produce respectively. Their research proves, SHP1 molecule can control the inflammation cell factor to secrete through inhibiting protein kinase and nuclear factor signal from transferring to and leading the thorough fare, and SHP1 molecule can inhibit the activation of IRAK1, makes macrophages and the tree can increase, secrete interferon to dash for ward form cells after discerning the pathogen, thus help the organism to inhibit the emergence of inflammation one's own immune disease while removing pathogen.

" the natural immunology" magazine spend space of P under 3, allot the question in order to " finely adjusts and controls TLR signal to transfer to leading " the special topic is commented on ", have offered high evaluation as to the innovative and potential application prospect of this research. Research this discern to the intersection of organism and immunity of immune system mechanism and immune the intersection of cell and the intersection of function and adjustment research and propose Singapore side to, also offered the new target and thinking for defending the virus and infecting and treating new medicine of one's own immune disease such as arthritis and designing. (Xiao Xin)



Study and obtain great progress in meticulous adjustment of immune system