Preceded on the function of the albumen in actin is

Preceded on the function of the albumen in actin is recombinated
Thesis author: JamesBear periodical: <>

(Front cover picture: The artistic double-colored kymograph picture demonstrates slice in the foot the skin moves a time order recombinated of azelon. )

The first albumen (coronin) It is a kind of highly conservative actin conjugated proteln, they lie in and move cells (motilecell) Leading edge district. " cells " (Cell) published on September 5, 2008 Have, scientists such as Cai from U.S.A.,etc. have announced and precededded the albumen 1B and given play to the mechanism of the function for the first time, their result of study is published on this issue of publication in the form of cover story.

Move surface of cell, have one the intersection of projection and the intersection of form and structure of flat section, known as one slice of feet (lamellipodia) ,This kind of structure is wide and flat on the shape, different from the microvilli, they relate to the engulfing of particulate matter. Relate to many kinds of cell course from actin relevant albumen - dendritic actin network that Arp2/3 compounds the body to emerge in one slice of feet, include forming, direction perceiving and migration of cells of the conspicuous thing,etc.. Though scientist's generation process to this network has been already very clear, but the inherent mechanism of decomposing in regulating the actin network still understands little.

In the article, the author says, preceded the albumen 1B decompose and include the actin filament branch of Arp2/3 by inducing the division of Arp2/3. And the above course and cortex protein (cortactin) Function is opposite, the little silk conjugated proteln cortex albumen is the important adjustment molecule of a kind of little silk too, it can act as the bearing, through activating Arp2/3 complex to promote the fast equipment in the cell leading edge district of little silk, achieve the goal of acting on cells and moving.

Just because there is such a biochemical competition course, the scientist observes under study for action, when two kinds of albumens both loss too, can resume one scene of feet dynamics defect that is caused partly by single loss of a certain albumen among them. Preceded albumen 1B act on the actin branch in a manner to compound the mutual exclusion of body with Arp2/3, and change its angle.

So author think, with dendritic maturity of network, preceded the intersection of albumen and 1B substitute Arp2/3 of actin filament among the one, compound the body, and reinvent the actin branch by changing the geometirc shape. (it is scientific what is great for brightness network /compile)

Preceded on the function of the albumen in actin is recombinated