Mucomembranous vaccine of innovative AIDS, are full of rational expectation

Mucomembranous vaccine of innovative AIDS, are full of rational expectation
Staff reporter Wang Lu

The language before compiling: AIDS threatens the challenging the most greatly of human health, are endangering social progress and economic growth seriously, it has been a world sexology difficult problem that vaccine of AIDS has been researched and developed all the time.

On September 24 this year, American and Thai researcher are announced together, both sides develop a kind of " unite vaccine " that is tested cooperatively Can be infected with the risk reducing 31.2% of HIV of the human body. This is the mankind acquisition has some AIDS vaccine which protect the result for the first time. Though this vaccine has a lot places waited to study and optimize, let people walking on the road to explore inspire again after all.

And in the comprehensive research central lab of AIDS in Tsing-Hua University more than one month later, mucomembranous vaccine of innovative AIDS which the research group that Professor Zhang LinQi has introduced them to the reporter is researching and developing. It, is bearing the weight of countless excitement and great expectations.

" our association is real Gold Triangle "

The Chinese Academy of Medical Sciences, Tsing-Hua University one Zhang LinQi Professor, Chinese Academy of Sciences Guangzhou biological medicine and health research institute president Professor Chen Lings former ( Specially engage) Mainstay of mucomembranous vaccine of innovative AIDS that in progress with Professor Chen ZhiWei of the AIDS research institute of Li Jiacheng medical college of University of Hong Kong at present. Three people, in three places separately, for a common goal. Chen Ling says, " we are real Gold Triangle " while interviewing by telephone .

This " Gold Triangle " Member many years ago at U.S.A. already know each other,but behind not coming back home for establishing by cooperation in joint undertaking which biological medicine study of China. But in 2008, the country that jointly applies by biological medicine and research institute of the health, University of Hong Kong, Tsing-Hua University in Guangzhou of Chinese Academy of Medical Sciences, the Chinese Academy of Sciences " Eleven five " " great infectious diseases such as AIDS and virus hepatitis,etc. are prevented and cured " The great project of science and technology " The research and development of mucomembranous vaccine of innovative AIDS " Let three getting intimate people these " Keep in touch " ,from then on,"Gold Triangle " Take shape formally. In more than one year, have made a result of study with important meaning in exploring and researching and developing vaccine of innovative AIDS etc., must use the report at 2009 World Conference on vaccine of AIDS just finished in Paris, and cause the concern.

"History in more than 20 years in the past proves, it is not enough to study vaccine forms of AIDS and depend on personal ability, it is not enough to even lean against specific country. In the face of this great world difficult problem, need big group's even transnational team unity. Experiences of us are different to some extent, but can have complementary advantages. " Chen Ling tells reporters. Before this, Chen Ling has made in the industrial circle for many years, and the first inventor who developed Ad5 vaccine as American Merck Company went through the whole procedure of vaccine. Zhang LinQi and Chen ZhiWei are colleague and good friend for many years in U.S.A., have made a series of important achievement in optimizing virus carriers of vaccine of the Temple of Heaven of our country, Chen ZhiWei has still made the research of virus AIDS vaccine of the 1st generation of non- mucomembranous vaccine, have settled solid foundation for research and development of mucomembranous vaccine of innovative AIDS. In addition, they have done very careful and extensive epidemiology investigation and field study in Yunnan, Xinjiang, Henan, Guangxi,etc. province of our country. All these have laid the foundation for three people tacit cooperation.

" our goal is mucomembranous vaccine of innovative AIDS "

In the comprehensive rearch centre of Tsing-Hua University AIDS, Zhang LinQi has introduced this result of study with important significance of mucomembranous vaccine of innovative AIDS to the reporter.

"The intersection of Merck and the intersection of failure and suggestion and it warns to be simple in order to induce T enough to block the spreading through sex intercourse of HIV in the intersection of vaccine and tactics of cellular reaction in we of vaccine, it is not enough to reduce the virus at the internal duplication level either. " Zhang LinQi says, " our innovative vaccine tactics are mucomembranous vaccine. The mucomembranous surface is in first line of defence which resists HIV, induces the high-efficient mucomembranous immunoreaction which resists HIV in the body to immune tactics of the mucous membrane through the target. "

Zhang LinQi says, utilizes basic virology and amynologic latest research results, pass to design and optimization of mucomembranous antigen, mucomembranous carrier, mucomembranous adjuvant and immune strategy, the ones that research and develop and can induce the protection properties and resist HIV's mucomembranous immunity and reply " Mucomembranous vaccine of innovative AIDS " ,It is their goal to block the channel that AIDS propagates through the sex.

In this research, Zhang LinQi,et al. finds through jointly using improving virus the Temple of Heaven one of vaccine (MVTT) Mucomembranous carrier vaccine and 5 type adenovirus carrier vaccine ( Ad5) Can control effectively, even totally prevent the mucomembranous route to the monkey of Ganges River of high pathogenic SIVmac239 virus to infect. And the national epidemic disease census data reveal, the AIDS fashion trend of our country has already begun to spread from high-risk group to the ordinary crowd, and this kind of diffusion is mainly infected through the mucomembranous route ' Contact of sex) .

Their immunity after assessing the vaccine intramuscular injection of first immunity of mucomembranous route of MVTT vaccine and Ad5 and strengthening the immunity in the monkey of Ganges River of China is original, result indicate the tactics in test monkey bring out high-level in the body and chronic cell immunity reply continuously.

Subsequently, even more important attacking the poisonous test shows, the immunity that jointly uses two kinds of different source virus carrier vaccines to bring out is replied, have controlled the high dosage effectively, the infection of the mucomembranous route of rectum to the monkey of Ganges River of impedance SIVmac239 virus of causing a disease, neutralizing antibodies that it is high or reduces the virus greatly in internal duplication.

" in 2011 years, we expected to achieve one's goal "

While interviewing, Chen Ling and the students of he Sun CaiJun emphasize vaccine of AIDS and study the importance of cooperating with group constantly. "The difficult problem that others can not capture does not mean the scientists of China can not capture either. " He says, vaccine of AIDS is studied and be said to be the highest medical difficult problem in the world at present, the research in this respect of China has already accumulated some strength and team. Can capture the fort first in the world, meaning its or satellite fly to the sky large than land on the moon, that just follows in sb.'s footsteps after all. "Hope the related departments can strengthen the input in this respect, this is not merely to China, it is China to panhuman contribution even more " .

And mucomembranous vaccine of this innovative AIDS totally has China's independent intellectual property rights. A reporter knows while interviewing, the Qi's scientific research group of a piece of forest is preparing the second batch of monkeys to test in full preparation, the monkey is selected and already basically finished.

"We hope can vaccine is tested at the beginning before the the end of the year, mainly increase quantity and contrast of testing animal, and optimize immune scheme, result and mechanism that further understand vaccine protects. " Chen ZhiWei of University of Hong Kong tells reporters through the mail.

Distance interview big already after the past two years will Chen while being last, it was the end of 2007 at that time, last day coming at a time he will return to Hong Kong. While talking, he has told reporters, the mucomembranous vaccinating that oneself is studying is an unyielding person, but they are trying every possible means to gnaw this hard bone.

Now, Chen ZhiWei's center is that mucomembranous vaccine is studied, by effective prevention HIV (mucous membrane) Spread. "our country pass ( Mucous membrane) The infection of spreading has already been a main problem, so prevent HIV (mucous membrane) The mucomembranous vaccine meaning of spreading is very important. " Chen ZhiWei says.

At present, " Gold Triangle " Going all out, plan to study further affirmation in second batch of Ganges River monkey's body.

"Once verify, we will launch the preparation of human clinical research at once. That will undoubtedly and slow down HIV to infect to blocking through the mucomembranous route ' Contact of sex) Have great scientific meaning and social effect in the ordinary crowd's prevalence of our country. " LinQi Zhang say recently, he turn down a lot of meeting already, at least 12 spend in laboratory hour every day on average. Mucomembranous vaccine study at first and cost the most expensive stage so far in monkey test developing this step, it is a very key step, they go on very prudently. There is no country " Eleven five " The support of the great project of science and technology, launch such horizontal scientific experimentation, it is totally impossible.

According to Zhang LinQi, it will be a key year in 2010. If monkey's test made good progress, the test result is satisfactory, would launch the clinical trial at once in 2011. The skillful one is, on the occasion of the hundredth anniversary of the founding of the school of Tsing-Hua University, University of Hong Kong in 2011, it will be that the biological medicine in Guangzhou and research institute of the health obtain five annual institutes that national Central Organization Committee Office accredite to celebrate too.

"We three people come back home, the heart serving country is very strong, will go all out. Beginning the clinical trial in 2011, it is the big hundredth anniversary of the founding of the school of Tsing-Hua University, Hong Kong that presents a gift, I hope to achieve one's goal. " Chen ZhiWei says.

Mucomembranous vaccine of innovative AIDS, are full of rational expectation