Thesis author: PirkkoVihko periodical: <
Thiamine form phosphatase (TMPase, is also called and able to bear Fluorine acid phosphatase) It is a small typical diameter that carries the neuronal tissue chemical mark thing of root ganglion. The molecular structure about TMPase is not so obvious at present.
" neuron " (Neuron) on October 9 On the magazine, Zylka,et al. discovers, TMPase and prostate acid phosphatase (PAP) Membrane last body the same,but know people molecular structure and functions physiological to PAP either.
Zylka research of group show, strike except that the intersection of PAP and little mouse of gene have normal acute sensitiveness of pain, the pain sensitiveness that and chronic inflammation and neuropathic pain react is strengthened. Find when studies in correlation of pain - functions: The vertebra is in charge of injecting PAP albumen and having more strongly easing pain and resisting the allergic function of the sense of pain, this kind of function can lengthen opium types to ease pain for function time of morphine. Through 5 ' the nucleotide enzyme inhibit pain, particularly, PAP can remove other phosphoric acid adenosine (AMP) outside the function PAP Adenosine behind activation A1 in spinal adenosine receptor.
So far, Zylka,etc. has expounded PAP molecular mechanism and physiological function between nucleotide supersession of purine and pain, thus has put forward the method that a new application PAP treats the chronic pain. (it is scientific it is military to be gentle in swallow in network /compile)
Acid phosphatase of prostate inhibits the pain mechanism
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