It influences the cellular metabolism of tumour that 3 kinds

It influences the cellular metabolism of tumour that 3 kinds prevent albumens
It is reported in the cold spring harbour laboratory (CSHL) of New York of U.S.A. Websites report recently, the researchers of this laboratory find in tumour cells 3 kinds prevent albumens, can influence two inferior editing of third ketoacid kinase, thus change the cellular metabolism mechanism. It's time to find that helps a scientist to understand and overcome and perplex the 80 -year long difficult problem of medical circle - -" tile Burger's effect " ,And will contribute to finding a and inhibiting the cellular metabolism of the tumour and growth new method of tumour. The publication of the relevant research results is on the recent network edition of " institute's publication of American national academy of sciences ".

1930s, Otto of German biochemist the intersection of tile and Burger find tumour and become body organize, store supersession difference in normally, they can produce through glycolysis, and produce a large number of by products - -Lactic acid. The the intersection of supersession and property make the intersection of tumour and cell dawdle candy speed far greater than normal cells. This kind of tumour cell can rely on the enhanced phenomenon to produce the glycoclastic thorough fare, called " tile Burger's effect " ,It will promote cell hyperplasia and tumour to grow extremely fast. And research has shown recently, it is one kind that has been named PK-M2 (third ketoacid kinase M2) Albumen last tumour the these of the cells kind to metabolize, be played an essential role to forming and growth of tumour.

One that PK-M2 is third ketoacid kinase is inferior type, but its another inferior PK-M1, different from M2, it is harmless. These two kinds are inferior type comes from the same gene - -PK-M gene. This gene montages according to different ways variable editing (namely mRNA forebody of the gene in a unique way, produce two kinds or many more kinds of mRNA) ,Two kinds are inferior type to produce M1 and M2. In tumour cells, why can the variable editing of PK-M gene only produce dangerous M2, and does not produce harmless M1, it has been a mystery all the time.

Research group that the cold spring harbour Professor Adrian and Clay and Nell of laboratory led in American New York, have sifted and checked the numerous editing factors in many type cancer cells, have found finally that prevents albumens in 3 kinds of editing of the decision M1 and M2 switch. Researchers find, the content in tumour cells of these 3 kinds of albumens is very high, it is they that have inhibited M1 inferior type editing, make tumour cells only produce M2. Through reducing the levels of these 3 kinds of albumens in cells, can reduce M2 level and lactic acid producing amount, resume production of M1, thus reverse " tile Burger's effect " to a great extent .

The intersection of Clay and Nell point out 3 these prevent albumen, hinder, bring up the rear, cell know the intersection of dead stop and production of M2, this indicates that there may be switches that other editing factors influence M1 and M2.

Group of this research is looking for other possible editing factors at present. And the normal supersession state of this kind of recovery will hinder the fast growth of tumour cells, remain to further study.

Clay and Nell says, though to " tile Burger's effect " Several basic problems have not been solved yet, has not known the function mechanism on this effect very much either at present, but the research about the cellular metabolism mechanism may contribute to unraveling this puzzle, thus find the new molecule medicine mark, develop and montage the factor to inhibit medicines and reversion " tile Burger's effect " Medicine,through last tumour cell supersession mechanism last cancer.

(Liu HaiYing)

It influences the cellular metabolism of tumour that 3 kinds prevent albumens