3 kinds of pre- processing measures can protect the heart

3 kinds of pre- processing measures can protect the heart brain operation patient
It is reported fourth army medical university west Vice President of Beijing hospital Xiong LiZe, department of cardiovascular surgery apt to make Hua, explore by several year by Professor and their the intersection of scientific research and group, make the great innovative achievement in non- ischemic preconditioning and aftertreatment protective action and common mechanism's research field on the heart brain, its research project " preconditioning and aftertreatment induce the ischemic application that tolerates mechanism and attentive brain while protecting " Obtain the first prize of progress prize in science and technology of Shaanxi Province of 2008 recently.

It is major operation and some special operation patient's postoperative disabling, lethal main reasons that it is poured into and damaged again that the heart brain is ischemic, lack effective the intersection of shelter and method still at being at present clinical, some operation enclose operation continue ischemic brain of taking place etc. period incidence damaged to pour into 2%~10%, mortality is up to 26%~60%; It is 1%~3.7% that the heart is ischemic to pour into the damaging rate again, mortality is 18%~32%. How prevent from, enclose the intersection of skill and issues of brain ischemic to pour into, damage, become the intersection of anaesthesia and important subject of field already again heart.

Xiong LiZe Professor,et al. study by system, propose preconditioning have apply the mechanism jointly for the first time in the world, and take the lead in verifying JAK/STAT is 3 kinds of non- ischemic and pretreated common signal thorough fares in cells. Find mitochondria damages etc. and produces the protective action of brain after the ischemic aftertreatment inhibits mPTP open, lightens ischemically, the application adenosine aftertreatment valve is replaced to the skill patient for the first time, the cardiac muscle is poured into and damaged after reducing the extracorporal circulatory system notably, make the application which encloses active medicine of a blood vessel of skill reduce by 29.7%, ICU detention time shortens to 3.1 days by 4.4 days. Apply hyperbaric oxygen, electric needle, 3 kinds of pre- processing measures of Fluorine ether narcotic drug to 2132 hearts and cranium brain operation patients, pour into and damage after obviously lightening the heart brain ischemically, the postoperative relevant complication reduces to 1.2% from 3.7%. (XiaoHong Ren WeiFeng Duan)



3 kinds of pre- processing measures can protect the heart brain operation patient