Thesis author: JagathRJunutula periodical: <
Antibody- Medicine conjugation links technology (ADC) It is a that abate the intersection of cancer cell and technology that medicine combines together the intersection of genetic engineering and the intersection of form and of antibody. On the " nature - biotechnology " periodical published in July, researchers report a new ADC technology with potentiality of treatment of cancer, this kind of method is expected to reduce medicines to the injury of health cells, the side effect is smaller too.
While discerning cancer cell sharply, the antibody taking tumour as target can neglect normal cells too, the characteristic of antibody use target for in research and development that medicine transport, researcher hope, tie up bunch, get these kind of antibody chemical the intersection of treatment and medicine, form ADC medicine. The method that made ADC medicine in the past has many kinds of mixing results, some antibodies will carry more medicines than other antibodies, so it is very difficult to confirm the best medicine consumption.
Nowadays, U.S.A. Genentech Company WilliamMallet and colleague can confirm ADC medicine to carry medicine quantity makes new method to develop a. Compared with method in the past, the therapeutic medicine of chemistry is tied up bunch on the antibody in a manner to can be bred, so side effects to health cells are less. They have revised the special location on the structure of the antibody what has been clicked in order to promote the medicine is tied up bunch, while will not influence the whole structure of the antibody or ability to discern cancer cell.
The study on little mouse of mode reveals, such new ADC medicine is more effective than the traditional ADC medicine: Only the medicine of half the dosage can kill as many cancer cells. Moreover, for rabbit and monkey, they have better tolerance to such new ADC medicine, mean there is smaller side effect on people in this kind of medicine. (Source: Scientific Times Wang DanHong)
New cancer treatment technology with little side effect
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