It is more effective to make vaccine of hepatitis B

It is more effective to make vaccine of hepatitis B the dosage
The old gaudy reporter of New Bulletin reporter Wu JianPeng

After five year, second " whether China chronic hepatitis B prevents and cures the guide " Announce recently. At the meeting, expert point out rate, crowd of infection, Chinese of hepatitis B drop to 7.18%, China high to change into intermediate and getting prevailing while being getting prevailing from hepatitis B already, this could not be separated from that our country insists for a long time the injection of vaccine of hepatitis B is. In the new edition " guide " announced this time, there is adjustment in the injection about vaccine of hepatitis B, the neonatal injection amount is by 5ug (microgram) before this ,Change into 10ug. Expert remind, say, play vaccine appear antibody or have antibody and person that disappear again want, watch situation choose, " mend, play " in time after the many years also ,In order to prevent hepatitis B from infecting effectively.

Current situation: The national infection rate is reduced, Guangdong is still high

With the hepatitis B vaccine injection for many years, the hepatitis B infection rate of our country obviously drops, it shows by the national hepatitis B epidemiology investigation result which China launches independently to release this time, the carrying rate of surface antigen of crowd's hepatitis B of national 1 to 59 years old, as 7.18% (9.75% in 1992) . The crowd that age is the less, the infection rate of hepatitis B is the greater in fall, the investigation reveals, the infection rate of 5 to 14 years old and crowd's hepatitis B of our country is 2.4%.

Chinese Medical Association the whole country infect with disease, learn Vice Chairman, southern the intersection of hospital and the intersection of hepatopathy and Hou JinLin Professor, director of centre, claim accept special visit, reporter of New Bulletin, greater than the infection rate of hepatitis B in the calling high and prevailingly area of 8% of the areas in the world, 2%~8% are intermediate and prevailing, under 2% low and getting popular, so our country from high to transfer to intermediate and getting prevailing while being getting prevailing already. "But Guangdong has been the large province of hepatitis B all the time, the investigation reveals, the infection rate of hepatitis B of Guangdong is higher than 8%, remaining high and popular area. " He claims, Guangdong has a large population to flow, and the coverage rate of vaccine does not cause the reason of still high infection rate of Guangdong enough.

Key: Neonate's injecting amount is increased by one time

Child have three injection vaccine according to regulation born, but 2 year old find that there is not hepatitis B antibody when the half physical examination. It is vaccine that has reacted on earth, or has the antibody disappeared after emerging?

Professor Hou JinLin claims, if produces antibodies, can generally maintain for more than 10 years after hitting vaccine of hepatitis B. There are no antibodies in the physical examination, may not produce antibodies at all after hitting vaccine.

This is because the neonate injected vaccine of hepatitis B was 5ug in the past, " high that 5ug had no rate that 10ug produced the antibody. " Professor Hou JinLin claims, many neonates have not produced antibodies after injecting. Therefore new " the guide " emphasize baby should in born, accept 10ug (microgram) in the 24 hour The hepatitis B vaccine injection of the dosage, so can be in order to improve and block mother-to-baby transmission and improve the rate that the neonatal antibody produces notably.

About 5% of the people have no antibody to hit vaccine for the first time

But vaccine of hepatitis B has had no antibody after Mr. Zhang has had three injection as requested, the doctor advises him to improve the dosage and make, there are no antibodies yet. What reason is this on earth?

Professor Hou JinLin claims, probably 5% people have no antibody after hitting vaccine for the first time, mainly there are four reasons: One some people very much difficult to produce antibody itself have; Second because individual difference lead to the fact to there is enough vaccine to these people regular dosage, should strengthen the dosage and make different types of hepatitis B vaccine once again; Three may the intersection of hepatitis B and recessive the infeted, the people fight vaccine, have no antibody even more, because his internal hepatitis B virus quantity is very low, two regular can not find half-and-half it has already been infected; Fourth, one's own low immunity its fight when the vaccine taking medicines of different immune inhibitor, because its organism is too weak in immunoreaction of vaccine, can't measure the surface antibody, this kind of people needs to choose the appropriate opportunity to reseed.

Countermeasure: The new " guide " is recommended the dosage to the low one of immunological function as 60ug / needle. "The person without antibody after hitting vaccine, can hit once again, if still there are not antibodies, should further measure hepatitis B and virus DNA, see whether hepatitis B and recessiveness are infected. " Professor Hou JinLin says.

The antibody should be mended and hit vaccine after disappearing

Miss Lin has injected vaccine of hepatitis B 8 years before, there are antibodies all the time in the previous physical examination, but unexpectedly the physical examination No of this year! Why?

The expert explains, the detection of the hepatitis B antibody is divided into two kinds, one determines the nature, namely from " negative, positive " To judge, the surface antibody shows that there are antibodies for being positive; One quantification, namely check internal antibody how much quantity have, take, drip degree, say generally. Quantification accurate than to determine the nature, determine the nature, because drip and measure low, show having no antibody often. Perhaps Miss Lin an antibody drips degree non- high, that can not measure.

"With the extension of time, it is a normal phenomenon that the quantity of the antibody is reduced. " Professor Hou JinLin claims, some people antibodies will even drop to the instrument and can not measure, but only produced antibodies, cells still have immune ability on hepatitis B, reseed 1~3 stitches of hepatitis B vaccine more at this moment, immunity against hepatitis B and virus will be stronger.

Countermeasure: Carry on antibodies quantitatively to measure, when being under 10mIU/ml, need to reseed vaccine of hepatitis B as dripping degree. It says, generally speaking that credit of hepatopathy of Chinese Medical Association is known to General Board Jia JiDong, the protection result with the person who replies antibody can last 12 years at least after inoculating vaccine of hepatitis B, common people do not need to monitor or hit vaccine again, but low to for instance, immunological function, other wounded incident, often contacting the personnel of the blood or often accepting blood transfusion or blood products, the positive mother give birth to high-risk group such as the neonate,etc., still propose monitoring regularly, strengthen the immunity if necessary.

It is more effective to make vaccine of hepatitis B the dosage