Cells remove the mechanism and study and make the break-through

Cells remove the mechanism and study and make the break-through to wither and die
It is reported ' Reporter Li TianShu) The cells one " Commit suicide " (wither and die) There are certain advantages on human body, but " commit suicide " Cell must clearing up in time,question it if you can't otherwise not know, cause. Recently, the intersection of Chinese Academy of Sciences and heredity and the intersection of development and in wither, die cell remove mechanism make the important break-through in the research biological research instit ute - -Find and wither that cells engulf a kind of adjustment mechanism of the receptor to die for the first time, and announce retromer participates in withering to die cells remove this new function. It is introduced, retromer is responsible for the compound body of reverse transportation of protein within cells. This finds that has offered the new thinking the emergence which studied human immune system and dise ase of nervous system.

To multicellular organism, procedural cell death develop to his individual constantly and the organization and trends of organ p lay an extremely important role steadily. However, cells are " committed suicide " by inside After the procedure withers and dies, must be fast adjacent cells or " full-time " If you can't phagocyte, engulf,combine finally by degradation lysosome. In addition, are removed in the nervous system through and similar mechanism by the cells damaged. When cells remove obstacle to wither and dying, will initiate a great deal of one's own immune system diseases, such as inflammation and lupus erythematosus,etc..

Remove, wither die cell, lie in, phagocyte to engulf receptor, should first discern, wither, lose cell surface. And then engulf receptor and include, wither, die to engulf low body swallow, phagocyte together, cell. Driving the mechanism out for entering within cells, researchers understand very few.

The beautiful nematode studies the procedural cell death and withers to die cells remove the importan t mode animal of the mechanism. The intersection of Chinese Academy of Sciences and heredity and the intersection of development and biological the intersection of research institute and high researcher of forest laboratory finding do ne on pretty nematode Yang, engulf releasing from engulfing on the small body of receptor, need participation of one retromer. When retromer compounds the body sudden change takes place, engulf at the cell membrane engulf the intersection of receptor and CED-1 and engulf the little body, transport to lysosome and will be degraded, cause the receptor phagocyting to lack and cause and wither to die the clearance obstacle of cells.

Study the thesis to issue and publish in the near future online <>Have. This research receives subsidy such as medium and long-term project, national natural science fund project of the Ministry of Science and Technology.



Cells remove the mechanism and study and make the break-through to wither and die