3 kinds of kinase related to Alzheimer's disease appear

3 kinds of kinase related to Alzheimer's disease appear
It is reported U.S.A. translates the hereditary research institute (TGen) One find group can initiate by tao albumen function the kinases of obstacle 3 kinds ( From can support body molecule to shift the intersection of phosphate group and group to particular the intersection of target and enzyme of member) while being high ,It is these 3 kinds of kinase that block the connection among the brain cell, and then caused the letheral question correlated to Alzheimer's disease. Researchers think, should find that contribute to developing new medicine which treats Alzheimer's disease. The relevant thesis is issued on the " BMC genomics " magazine published in the near future.

Tao albumen is that one kind connects the albumen that forming of the bridge plays an important role to little tube among nerve cell. This kind of one that is in charge of being like the nerve cell in the bridge a little " The skeleton " ,Support to touch and connect suddenly, make among the nerve cell if the circuit of the computer can communicate each other equally. If the intersection of tao and the intersection of albumen and function appear obstacle, cause, can't connect each other among the nerve cell, thus influence people's cognition seriously, namely think and deduce ability.

TGen nerve Travis Dr. Dunkerley, assistant researcher of research group of sex change writes articles to point out, in normal cases, kinase adjust the intersection of tao and albumen through increasing phosphoric acid, this piece name the intersection of tao and the intersection of albumen and phosphorylated course can make the little tube tied definitely after untying, make the nerve cell connect each other, thus promote forming and maintenance of man memory.

But tao will excessive phosphorylation in albumen sometimes, in charge of the bridge can be disassembled, lead to the fact neural fibril tangles a little. And neural fibril tangles are one of the pathologic characteristics of model of Alzheimer's diseases.

This research group uses a kind of molecule tool which is named siRNA, has carried on complicated test to all known ones and what the theory is reasoned out in human cells and 572 pieces of kinase, have confirmed 26 pieces of kinase related to tao albumen phosphorylation finally, and 3 kinds of kinase EIF2AK2, DYRK1A and AKAP13 among them have caused the excessively phosphorylating of tao albumen, thus disassemble and in charge of the bridge a little permanently.

The intersection of TGen and the intersection of nerve and hereditary clinical director of credit portion, it is bar that receive the intersection of Alzheimer and the intersection of disease and the intersection of research institute and the intersection of Eric and the intersection of Lehman and Dr. of executive director, explain at the same time, tao albumen nerve cell in " The skeleton " Combine together, as the albumen conglutination of phosphoric acid molecule and tao, this " skeleton " Disintegrate, the nerve cell begins to retract and touch the branch and combine death suddenly, cause memory and lose and think ability goes wrong. And through siRNA, researcher can conclude which kind of it is albumen inspire the intersection of phosphoric acid and molecule and the intersection of tao and bonding of albumen.

Lei Man claims, these 3 kinds of kinase may inhibit the target of the medicine from being ordered as albumens now. If can develop a medicine curing neural fibril tangles safe, with very good tolerance, will bring the hope to Alzheimer's treatment of disease. Their next task, want to find and confirm the medicine composition invalidating these 3 kinds of kinase. (Liu HaiYing)

3 kinds of kinase related to Alzheimer's disease appear