The network function disorder of the inner quality will increase

The network function disorder of the inner quality will increase the fat to decompose
It is reported ' Reporter Fu DongHong) Peking University basic the intersection of medical college and physiology whether fat and the intersection of country and permanent the intersection of professor and a research of seminar Xu, research room of supersession, show, what the inner quality net should surge exists continuously, will cause disorder of fat of blood, lipoprotein toxicity and emergence that insulin resisted finally, until the intersection of quality and network should defy emergence that insulin resist under the state offer new the intersection of cell and biological basis in the fat and diabetes,etc.. It is biological that the relevant research thesis is in the internationally famous periodical recently " The Chemicals is " issued on the network.

Xu GuoHeng introduces, under the function of lipase, triglyceride is hydrolyzed for the course of glycerine and free fatty acid in the fat cell, the fat is decomposed. Fat decomposition reaction releases the free fatty acid, organize offering energy for whole body on one hand, on the other hand regulate fatty acid level and whole body energy balance in the blood. The fat will cause fatty acid density in the blood to rise while decomposing excessively, this is the main reason that insulin takes place to resist in fat and diabetes.

It is small that the inner quality network exists in animal and human cell " The organ " ,Have many kinds of important functions, for instance the ones that participated in the protein are synthetic, transships. In cases fat, diabetes,etc. are pathologic, the unusual change may take place in the inner quality network function of cells, should surge and react to cause a series of inner quality network, and therefore change the function of cells. Inner the intersection of quality and network cell formate triglyceride and form place that oil drip, light oil that form newly drip, bring the intersection of quality and omentum and protein under one and transport to the cytoplasm. Consider the triglyceride and oil are dripped and produced in the inner quality network, and is still in close relation with inner quality network behind transporting to the cytoplasm, the intersection of country and permanent seminar Xu study the intersection of fat and decompose and inner the intersection of quality and the intersection of network and connection should defy, that oil drip. Research verifies, different inner quality networks should be surged to induce pharmaceuticals to stimulate triglyceride of the big mouse's fat cell to decompose effectively.

It is reported, under fat and diabetes pathologic condition, very strong inner quality network happens and should be surged, reacted in Langerhans' islits cells, the hepatocyte and fat cell in recent years. The permanent seminar in the Xu 's studies to show, the fat is decomposed and increased when the inner quality network should defy, may one the intersection of adaptability and the intersection of regulation and response mechanism of energy balance that organism produce; But if the inner quality network should be surged and existed continuously, will make the fat decompose and release and enter the blood to increase with the free fatty acid continuously, will cause disorder of fat of blood, lipoprotein toxicity and emergence that insulin resisted finally. The more serious one is, the quality network should defy in the raised free fatty acid will be further aggravated continuously, the latter can continue stimulating fat decomposing and fatty acid release, thus fall into the vicious circle.



The network function disorder of the inner quality will increase the fat to decompose