Giving a new lease of life to antibiotic can be

Giving a new lease of life to antibiotic can be killed and able to bear the medicine bacterium fatally
It is reported that organizes the report on August 24 of network, the scientist of Scripps research institute of American, to a kind of important natural antibiotic according to the American physicist - -Mould and plain (vancomycin) through the ages Succeed in carrying on the transformation, enable it to kill the mutant mortality and is able to bear the antibiotic bacterium. It is expected to be used in clinic in the future that this kind gives a new lease of life to antibiotic, treating those infects high patient able to bear the nature bacterium. More important, give a new lease of life to preparation method of antibiotic, capture many kinds of variation, able to bear the intersection of medicine and fungus, bring, hope for people. This research is published on " U.S.A.'s chemical association's proceedings " websites.

On clinic, only the patient has been infected with and able to bear golden yellow staphylococcus (MRSA) of west forest of first oxygen Or just use to penicillin, pioneer mouldly through the ages to usually treat when being mould and plain and allergic. Began to use in the fifties of mould plain last century through the ages, the ones that found first kind of it in the eighties were able to bear the medicine fungus. It can seize a kind of necessary raw materials peptide that the bacterium makes its cell wall and gather candies, let the bacterium be unable to get them but dead. But make a variation the bacterium can express the body of variation that peptides gathered the candy, changes a key atom among them, gather peptide a piece of amide in the candy chemical formula to turn into a ester.

The function between the molecules exists and attracts and repels too just like the magnet. Once attracted and let them repel most now in the mould and plain position through the ages most, it was unable to discern such mutant bacterium. What researchers do is the interaction of controlling the function molecule, let them not repel again, but attract each other.

Scripps research institute chemical professor Dell and Bogg says, it is a mould and plain imitation through the ages of natural antibiotic that this kind gives a new lease of life to antibiotic. Though this research is still at primary stage, just design the function molecule, but demonstrate a lot are leading.

They have changed the molecule in the key position in the mould plain key structure through the ages according to the chemical property of the function molecule. Then do relevant to decorate when being remaining and 4 piece amino, connect upper amidine as discern, make a variation peptide gather function member group of candy. Antibiotic after transforming can seize peptide after making a variation and gather candies, make able to bear the medicine fungus and can't get the raw materials which make the cell wall again again, thus killed them. A key one most, these give a new lease of life to antibiotic, keep with original ecological peptide gathering ability that candying combining also.

Compared with existing many steps production process, the new method connects the molecule amidine of function in the last step, become a kind of single step chemical reaction, this is a simplest and directest method. "But the speech from formating the chemical angle, such simple preparation method is a great break-through. " First thesis author, the intersection of Bogg and the intersection of group and graduate student thank and build ' Transliteration) Say. Method this verify can large-scale production these kind gives a new lease of life to antibiotic in the laboratory already.

Researcher point out the antibiotic that give a new lease of life to manually oppose the intersection of mankind and able to bear the intersection of medicine and the intersection of fungus and, having potentiality greatly most serious still. New research has revealed the developing direction of antibiotic of future generation of the super bacterial infection of treatment, have important clinical meanings.

(often beautiful monarch)

Giving a new lease of life to antibiotic can be killed and able to bear the medicine bacterium fatally